DETERMINING THE FUNCTIONAL ROLE OF METHYLATION OF PGC1ALPHA

确定 PGC1α 甲基化的功能作用

• 批准号: 8171358
• 负责人: Michael R Stallcup
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171358
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Estrogen Receptors; Funding; Glucocorticoid Receptor; Grant; Institution; Methylation; Nuclear Receptors; PPAR gamma; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; nuclear respiratory factor; transcription factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) has been shown to be an important coactivator that regulates the activity of several nuclear receptors (NR) such as estrogen receptor (ER) and glucocorticoid receptor (GR); as well as transcription factors such as nuclear respiratory factor 1 (NRF-1).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 过氧化物酶体增殖物激活受体γ辅激活因子1 α（PGC-1 α）是一种重要的辅激活因子，可调节多种核受体（NR）如雌激素受体（ER）和糖皮质激素受体（GR）以及转录因子如核呼吸因子1（NRF-1）的活性。