Impaired Decision-Making and the Role of Dopamine in Modulating Executive Function in Parkinson’s Disease

帕金森氏症（PD）患者的决策能力经常受到严重损害，即使在疾病的早期阶段也是如此。该项目将结合心理物理学、药物治疗和功能神经影像学来检查PD患者的决策障碍，以及多巴胺如何调节这些障碍。我们期望我们的发现将导致PD中执行功能障碍综合征的诊断和管理的改进。

Patients with Parkinson’s Disease (PD) often experience significant impairments in their ability to make decisions, even in the earliest stages of the disease. This project will use a combination of psychophysics, pharmacotherapy and functional neuroimaging to examine the decision-making impairments that occur in PD, and how they are modulated by dopamine. We anticipate our findings will lead to improvements in the diagnosis and management of the syndromes of executive dysfunction seen in PD.