Impaired Decision-Making and the Role of Dopamine in Modulating Executive Function in Parkinson’s Disease

决策受损以及多巴胺在调节帕金森病执行功能中的作用

• 批准号: nhmrc : 1053226
• 负责人: Dr Trevor Chong
• 金额: $ 26.04万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impaired-decision-making-parkinsons-disease/112321
• 关键词: Impaired; Decision; Making; Role; Dopamine

Patients with Parkinson’s Disease (PD) often experience significant impairments in their ability to make decisions, even in the earliest stages of the disease. This project will use a combination of psychophysics, pharmacotherapy and functional neuroimaging to examine the decision-making impairments that occur in PD, and how they are modulated by dopamine. We anticipate our findings will lead to improvements in the diagnosis and management of the syndromes of executive dysfunction seen in PD.

帕金森病（PD）患者的决策能力经常受到严重损害，即使在疾病的早期阶段也是如此。该项目将使用心理物理学，药物治疗和功能性神经影像学的组合来检查PD中发生的决策障碍，以及它们如何被多巴胺调节。我们预计我们的研究结果将导致PD中执行功能障碍综合征的诊断和管理的改善。