BRANCHED CHAIN AMINO ACID TRANSAMINASE

支链氨基酸转氨酶

• 批准号: 8170618
• 负责人: Lee W Tremblay
• 金额: $ 0.27万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170618
• 关键词: Amino Acids; Complement; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug Delivery Systems; Enzymes; Essential Amino Acids; Funding; Grant; Human; Institution; Kinetics; Lead; Pathway interactions; Proteins; Research; Research Personnel; Resources; Source; Transaminases; Tuberculosis; United States National Institutes of Health; Work; branched-chain-amino-acid transaminase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Branched-Chain-Amino-Acid Transaminase enzymes (IlvE) are part of the bacterial biosynthetic pathway for the denovo synthesis of this class of amino acids. These are dietary essential amino acids for humans, making the bacterial transaminase a good drug target for this unique bacterial pathway. The tuberculosis (Tb) Ilve protein has been crystallized in hopes that the structural understanding of this enzyme will lead to potential new therapies for the treatment of this disease. The crystal strucuture will complement our kinetic work on this enzyme and a through understanding of this key component of this essential bacterial biosynthetic pathway.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 支链氨基酸转氨酶（IlvE）是细菌生物合成途径的一部分，用于此类氨基酸的从头合成。这些是人类的膳食必需氨基酸，使细菌转氨酶成为这种独特细菌途径的良好药物靶标。 结核病（Tb）Ilve蛋白已经结晶，希望这种酶的结构理解将导致治疗这种疾病的潜在新疗法。 晶体结构将补充我们对这种酶的动力学工作，并通过了解这种重要的细菌生物合成途径的关键组成部分。