EM STUDY OF THE AUTOPHAGY PATHWAY AFTER BRAIN ISCHEMIA

脑缺血后自噬途径的电镜研究

• 批准号: 8169624
• 负责人: Bingren Hu
• 金额: $ 1.19万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169624
• 关键词: Autophagocytosis; Brain Ischemia; Computer Retrieval of Information on Scientific Projects Database; Electron Microscopy; Funding; Grant; Impairment; Institution; Ischemia; Light; Pathway interactions; Proteins; Reperfusion Therapy; Research; Research Personnel; Resources; Source; Tissue Sample; Transient Cerebral Ischemia; United States National Institutes of Health; electron tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this proposal is to investigate impairment of the autophagy pathway after transient cerebral ischemia followed by reperfusion. Our approach will rely on a combination light and electron microscopy to assess the effect of ischemia on the autophagy pathway and associated proteins. The use of wide-field electron tomography in particular should significantly increase the efficiency with which we can examine tissue samples and thereby increase the power of this study.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该提案的目的是研究短暂脑缺血后自噬途径的损害，然后再灌注。我们的方法将依靠组合光和电子显微镜来评估缺血对自噬途径和相关蛋白质的影响。尤其是宽场电子断层扫描的使用应显着提高我们可以检查组织样品的效率，从而提高本研究的功能。