THE ROLE OF ACTIVITY IN SCULPTING NEURONAL FORM AND FUNCTION

活动在塑造神经元形态和功能中的作用

• 批准号: 8169648
• 负责人: ROGER A NICOLL
• 金额: $ 0.84万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169648
• 关键词: Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Morphology; Mus; N-Methyl-D-Aspartate Receptors; Neurons; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; neuronal excitability; time interval

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will examine the role of activity in controlling the excitability and morphology of neurons. We have succeeded in making conditional mice in which we can, in a cell autonomous manner, silence all excitatory input to that neuron, by deleting all AMPA and NMDA receptors. These neurons can then be studied over various time intervals after silencing to examine the effects on neuronal excitability and morphology.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目将研究活动在控制神经元兴奋性和形态方面的作用。我们成功地培育出了条件小鼠，在这种小鼠中，我们可以通过删除所有 AMPA 和 NMDA 受体，以细胞自主的方式沉默该神经元的所有兴奋性输入。然后可以在沉默后的不同时间间隔内研究这些神经元，以检查对神经元兴奋性和形态的影响。