MISMATCH RECOGNITION BY MSH2-MSH6

MSH2-MSH6 的不匹配识别

基本信息

  • 批准号:
    8171881
  • 负责人:
  • 金额:
    $ 0.11万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-08-01 至 2013-07-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Post-replication DNA mismatch repair is an essential and highly conserved mechanism to ensure genetic fidelity. The first step in DNA mismatch repair is recognition of DNA base mismatches and insertion or deletions by MutS in bacteria and MSH complexes in eukaryots. The structure for the MSH2-MSH6 complex which recognizes base mismatches and short base insertions has recently become available from crystallography and will be used as the starting point for extensive computational studies to elucidate atomistic details of the mechanism by which mismatch repair is initiated. One aim is to carry out molecular dynamics simulations of MSH2-MSH6 over 100 ns time scales to study allosteric coupling between mismatch recognition and ATPase activity that would lead to conformational changes in MSH2-MSH6 to signal repair initiation. A second aim is to examine the detailed interaction between MSH2-MSH6 and DNA to understand the mechanism by which defective DNA is distinguished from regular DNA by employing biased simulations with a new biasing potential that facilitates translocation of MSH2-MSH6 along DNA. The immediate goal of the development account is to determine the best choice of simulation software and TeraGrid platform in preparation for an MRAC proposal.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Michael Feig其他文献

Michael Feig的其他文献

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{{ truncateString('Michael Feig', 18)}}的其他基金

Modeling and dynamics of biomolecules on cellular scales
细胞尺度上生物分子的建模和动力学
  • 批准号:
    9899820
  • 财政年份:
    2018
  • 资助金额:
    $ 0.11万
  • 项目类别:
Modeling and dynamics of biomolecules on cellular scales
细胞尺度上生物分子的建模和动力学
  • 批准号:
    9484503
  • 财政年份:
    2018
  • 资助金额:
    $ 0.11万
  • 项目类别:
Modeling and dynamics of biomolecules on cellular scales
细胞尺度上生物分子的建模和动力学
  • 批准号:
    10364749
  • 财政年份:
    2018
  • 资助金额:
    $ 0.11万
  • 项目类别:
Multiscale modeling of supramolecular protein-DNA assemblies
超分子蛋白质-DNA 组装体的多尺度建模
  • 批准号:
    8535786
  • 财政年份:
    2010
  • 资助金额:
    $ 0.11万
  • 项目类别:
Multiscale modeling of supramolecular protein-DNA assemblies
超分子蛋白质-DNA 组装体的多尺度建模
  • 批准号:
    7862767
  • 财政年份:
    2010
  • 资助金额:
    $ 0.11万
  • 项目类别:
Multiscale modeling of supramolecular protein-DNA assemblies
超分子蛋白质-DNA 组装体的多尺度建模
  • 批准号:
    8147721
  • 财政年份:
    2010
  • 资助金额:
    $ 0.11万
  • 项目类别:
Protein structure refinement through effective sampling and scoring
通过有效采样和评分细化蛋白质结构
  • 批准号:
    8035673
  • 财政年份:
    2010
  • 资助金额:
    $ 0.11万
  • 项目类别:
Multiscale modeling of supramolecular protein-DNA assemblies
超分子蛋白质-DNA 组装体的多尺度建模
  • 批准号:
    8327188
  • 财政年份:
    2010
  • 资助金额:
    $ 0.11万
  • 项目类别:
MISMATCH RECOGNITION BY MSH2-MSH6
MSH2-MSH6 的不匹配识别
  • 批准号:
    7956342
  • 财政年份:
    2009
  • 资助金额:
    $ 0.11万
  • 项目类别:
Protein structure refinement through effective sampling and scoring
通过有效采样和评分细化蛋白质结构
  • 批准号:
    8142756
  • 财政年份:
    2008
  • 资助金额:
    $ 0.11万
  • 项目类别:

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