ENERGY DISPERSION OF PROTEIN LAUE DIFFRACTION SPOTS

蛋白质 Laue 衍射点的能量色散

• 批准号: 8171974
• 负责人: Timothy J. Graber
• 金额: $ 4.01万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171974
• 关键词: Characteristics; Computer Retrieval of Information on Scientific Projects Database; Dimensions; Disease; Funding; Grant; Institution; Laws; Measures; Pattern; Physiologic pulse; Proteins; Research; Research Personnel; Resources; Roentgen Rays; Source; Spottings; United States National Institutes of Health; research study; small molecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In a diffraction experiment each set of planes (hkl) with spacing d in the single crystal acts as a monochromator that must satisfy Bragg?s Law. Each set of planes thus gives rise to a single ?reflection? (spot) in the diffraction pattern with extensions which is defined by a crystal disorder, finite dimensions of the crystal and the beam etc., and spectral characteristics of the beam. For polychromatic X-Ray beam (pink beam) spots occur from crystal in Laue diffraction pattern. In proposed experiment we shall measure energy dispersion of a single pulse of the pink beam by a small molecule/ protein crystal and compare it to the spectral characteristics of the undulator. The energy profile of the X-Ray beam reflected by (hkl) plane of the crystal will be studied using Si single crystal analyzer placed after the crystal diffractor.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在衍射实验中，单晶中每组间距为d的平面(Hkl)充当单色器，它必须满足布拉格？S定律。因此，每一组平面都会产生单一的反射？由晶体无序、晶体和光束的有限尺寸等以及光束的光谱特性定义的具有延展的衍射图中的(光斑)。对于多色X射线束(粉色束)，在劳厄衍射图中出现了来自晶体的斑点。在拟议的实验中，我们将测量粉红色光束通过小分子/蛋白质晶体的单个脉冲的能量色散，并将其与波动器的光谱特性进行比较。利用放置在晶体衍射器后面的硅单晶分析仪，研究X射线束在晶体(Hkl)面上反射的能量分布。