OBSTETRIC-FETAL PHARMACOLOGY RESEARCH UNITS NETWORK

产胎药理学研究单位网络

基本信息

  • 批准号:
    8172648
  • 负责人:
  • 金额:
    $ 0.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-05-01 至 2011-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The University of Texas Medical Branch (UTMB) has the capability to participate actively as a member of the Obstetric-Fetal Pharmacology Research Units (OPRU) Network. Gary Hankins, MD, as PI, is responsible for the proposed clinical trial on the use of hypoglycemic drugs in the treatment of diabetes during pregnancy. He has extensive experience within several NIH multicenter trials, eg, First and Second Trimester Evaluation of Risk of Aneuploidy (FASTER), Beneficial Effects of Antenatal Magnesium Sulfate Study (BEAM), and the Vaginal Ultrasound Cerclage Trial. Dr. Hankins has achieved successful patient recruitment and retention by involvement with UTMB's Regional Maternal & Child Health Program (RMCHP). All RMCHP clinics follow protocols established by the Maternal-Fetal Medicine division, headed by Dr. Hankins. Over 12,000 pregnant women are cared for annually within the RMCHP clinic system, approximately 7,000 of whom deliver at UTMB. The Pharmacology/Pharmacokinetics (PK) Co-Investigator, Mahmoud S. Ahmed, PhD, has over 25 years of expertise in utilizing human placenta and derived preparations in his investigations. Dr. Ahmed is a laboratory-pioneered investigator in placental receptors, their natural ligands and mediated responses, as well as the mechanism of hCG release from trophoblast tissue. They investigated the effects of in vitro and in vivo chronic administration of opiates on placental physiology and maternal-neonatal outcome. Utilizing dual perfusion of placental lobule, they demonstrated the influence of efflux protein and placental metabolic [enzymes on the PK for placental transfer of opiates. They identified placental aromatase as a drug-metabolizing enzyme and are investigating its polymorphism.
这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者(PI)可能从另一个NIH来源获得了主要资金, 因此可以在其他CRISP条目中表示。所列机构为 研究中心,而研究中心不一定是研究者所在的机构。 德克萨斯大学医学分支(UTMB)有能力作为产科-胎儿药理学研究单位(OPRU)网络的成员积极参与。加里汉金斯,医学博士,作为PI,是负责拟议的临床试验使用降糖药物治疗糖尿病在怀孕期间。他在几项NIH多中心试验中拥有丰富的经验,例如,非整倍体风险的早期和中期评估(FASTER),子宫硫酸镁研究(BEAM)的有益作用和阴道超声环扎试验。Hankins博士通过参与UTMB的区域妇幼保健计划(RMCHP)成功招募和留住了患者。所有RMCHP诊所都遵循由汉金斯博士领导的母胎医学部门制定的协议。每年有12 000多名孕妇在RMCHP诊所系统内接受护理,其中约7 000人在UTMB分娩。药理学/药代动力学(PK)合作研究者Mahmoud S. Ahmed博士在研究中利用人类胎盘和衍生制剂方面拥有超过25年的专业知识。Ahmed博士是胎盘受体、其天然配体和介导反应以及滋养层组织释放hCG机制的实验室先驱研究者。他们研究了体外和体内长期给予阿片类药物对胎盘生理学和母婴结局的影响。利用胎盘小叶的双重灌注,他们证明了外排蛋白和胎盘代谢酶对阿片类药物胎盘转运PK的影响。他们将胎盘芳香酶确定为一种药物代谢酶,并正在研究其多态性。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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GARY D HANKINS其他文献

GARY D HANKINS的其他文献

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{{ truncateString('GARY D HANKINS', 18)}}的其他基金

Pharmacokinetic and pharmacogenomic approach to indomethacin therapy in pregnancy
妊娠期吲哚美辛治疗的药代动力学和药物基因组学方法
  • 批准号:
    9211358
  • 财政年份:
    2015
  • 资助金额:
    $ 0.32万
  • 项目类别:
Pharmacokinetic and pharmacogenomic approach to indomethacin therapy in pregnancy
妊娠期吲哚美辛治疗的药代动力学和药物基因组学方法
  • 批准号:
    8839060
  • 财政年份:
    2015
  • 资助金额:
    $ 0.32万
  • 项目类别:
OBSTETRIC-FETAL PHARMACOLOGY RESEARCH UNITS NETWORK
产胎药理学研究单位网络
  • 批准号:
    8357647
  • 财政年份:
    2011
  • 资助金额:
    $ 0.32万
  • 项目类别:
Bupropion for smoking cessation during pregnancy
安非他酮用于怀孕期间戒烟
  • 批准号:
    8598865
  • 财政年份:
    2010
  • 资助金额:
    $ 0.32万
  • 项目类别:
Bupropion for smoking cessation during pregnancy
安非他酮用于怀孕期间戒烟
  • 批准号:
    8278587
  • 财政年份:
    2010
  • 资助金额:
    $ 0.32万
  • 项目类别:
Bupropion for smoking cessation during pregnancy
安非他酮用于怀孕期间戒烟
  • 批准号:
    8144932
  • 财政年份:
    2010
  • 资助金额:
    $ 0.32万
  • 项目类别:
Bupropion for smoking cessation during pregnancy
安非他酮用于怀孕期间戒烟
  • 批准号:
    8787725
  • 财政年份:
    2010
  • 资助金额:
    $ 0.32万
  • 项目类别:
OBSTETRIC-FETAL PHARMACOLOGY RESEARCH UNITS NETWORK
产胎药理学研究单位网络
  • 批准号:
    7957894
  • 财政年份:
    2009
  • 资助金额:
    $ 0.32万
  • 项目类别:
OBSTETRIC-FETAL PHARMACOLOGY RESEARCH UNITS NETWORK
产胎药理学研究单位网络
  • 批准号:
    7716073
  • 财政年份:
    2008
  • 资助金额:
    $ 0.32万
  • 项目类别:
OBSTETRIC-FETAL PHARMACOLOGY RESEARCH UNITS NETWORK
产胎药理学研究单位网络
  • 批准号:
    7562443
  • 财政年份:
    2007
  • 资助金额:
    $ 0.32万
  • 项目类别:

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运动对骨骼肌 Aromatase/17β-estradiol 通路的影响及功能研究
  • 批准号:
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衰老过程中芳香酶的翻译后调控
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支持大脑芳香酶控制摄食行为和代谢稳态的神经解剖学基质
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  • 财政年份:
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Comprehensive multi-omic analyses of "islands of resistance" tumour cells to identify aromatase inhibitor resistant subclones in ER+ breast cancer
对“耐药岛”肿瘤细胞进行全面的多组学分析,以鉴定 ER 乳腺癌中芳香酶抑制剂耐药的亚克隆
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  • 财政年份:
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基于网络的疼痛应对技能培训,以改善乳腺癌幸存者芳香酶抑制剂相关关节痛引起的疼痛和依从性差(SKIP-关节痛):一项随机对照试验
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Web-based Pain Coping Skills Training to Improve Pain and Poor Adherence caused by Aromatase Inhibitor-Associated Arthralgia In Breast Cancer Survivors (SKIP-Arthralgia): A Randomized Controlled Trial
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  • 批准号:
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酒精和 p450 芳香酶之间的相互关系
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