NATIONAL HIV BEHAVIORAL SURVEILLANCE SYSTEM

描述（由申请人提供）：马里兰州卫生和心理卫生部（DHMH），传染病和环境卫生管理局要求美国卫生和人类服务部，疾病控制和预防中心（CDC）在五年内提供4，018，636美元，以在马里兰州巴尔的摩-陶森大都市区实施国家艾滋病毒行为监测系统（NHBS）。NHBS是一项匿名研究，重点招募三种艾滋病毒感染风险人群：男男性行为者（MSM），注射毒品使用者（IDU）和艾滋病毒感染风险增加的异性恋者（HET）。这项研究将包括一系列的五个横断面调查，使用相同的访谈工具，将招募上述风险人群（1年和4年的MSM，2年和5年的IDU，3年的HET）。拟定的样本量为每年至少500名MSM和IDU人群参与者和450名HET人群。拟议的研究将包括一份详细的问卷调查，以收集有关人口统计学、性和药物使用行为、艾滋病毒检测和当地艾滋病毒利用的信息。 预防方案服务。调查问卷将在全国范围内标准化，并增加了巴尔的摩特有的有限问题。该研究还将提供HIV检测，利用FDA批准的HIV诊断检测和近期HIV血清转化的血清学检测算法（STARHS）来识别近期感染。抽样和招募方法将根据每个目标人群的情况选择，并将与疾病预防控制中心合作制定。MSM招聘将以场地为基础。公共场所（例如，酒吧、俱乐部等）在巴尔的摩市，将随机抽样，并将系统地与男性进行招募。IDU和HET招募将采用应答者驱动抽样（RDS）。最初的注射吸毒者和高危人群参与者将通过关键的社区线人招募，然后接受培训，以招募其风险群体的其他成员。一批又一批的注射吸毒者/高危贩运者新兵将招募更多的注射吸毒者/高危贩运者。要求提供补充资金，用于在所有五年内进行B和C型肝炎检测，在第一年内招募200名使用RDS的男性到女性变性参与者，并在第一年内收集额外的血液样本进行进一步的艾滋病毒检测。NHBS将提供有价值的信息，用于衡量艾滋病毒风险行为，以规划和针对马里兰州的艾滋病毒预防活动，并在该国受影响最严重的地区对高危人群的艾滋病毒风险行为进行全国估计。

DESCRIPTION (provided by applicant): The Maryland Department of Health and Mental Hygiene (DHMH), Infectious Disease and Environmental Health Administration is requesting $4,018,636 over five years from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC) to implement the National HIV Behavioral Surveillance System (NHBS) in the Baltimore- Towson, Maryland metropolitan area. The NHBS is an anonymous research study which focuses on recruiting three populations at risk for HIV infection: Men who have sex with men (MSM), injection drug users (IDU), and heterosexuals at increased risk for HIV infection (HET). This study will consist of a series of five cross-sectional surveys using the same interview instrument, which will recruit each of the above risk populations (MSM in years 1 and 4, IDU in years 2 and 5, HET in year 3). The proposed sample size is an annual minimum of 500 participants for the MSM and IDU populations and 450 for the HET population. The proposed study will include a detailed questionnaire to gather information on demographics, sexual and drug use behaviors, HIV testing, and utilization of local HIV prevention program services. The questionnaire will be standardized nationally, with the addition of a limited number of questions specific to Baltimore. The study will also offer HIV testing, utilizing both FDA approved HIV diagnostic tests and the Serologic Testing Algorithm for Recent HIV Seroconversion (STARHS) for the identification of recent infections. The sampling and recruitment methodologies will be selected as appropriate for each of the target populations and will be developed in collaboration with the CDC. MSM recruitment will be venue-based. Public venues (e.g., bars, clubs, etc.) in Baltimore City will be randomly sampled and men will be systematically approached for recruitment. IDU and HET recruitment will utilize respondent driven sampling (RDS). Initial IDU and HET participants will be recruited through key community informants and then be trained to recruit additional members of their risk group. Successive waves of IDU/HET recruits will recruit additional IDUs/HETs. Supplemental funding is requested to perform hepatitis B and C testing during all five years, to recruit 200 male to female transgendered participants using RDS during the first year, and to collect additional blood specimens for further HIV testing during the first year. The NHBS will produce valuable information for measuring HIV risk behaviors for planning and targeting HIV prevention activities in Maryland, and for producing national estimates of HIV risk behaviors in high-risk populations in the most affected regions of the country.