Cage Wash Expansion and Renovation in University of Missouri's School of Medicine

密苏里大学医学院笼清洗扩建和改造

• 批准号: 8185467
• 负责人: LONNY W DIXON
• 金额: $ 50万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2013-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8185467
• 关键词: Allergens; Animals; Area; Diabetes Mellitus; Equipment; Exposure to; Faculty; Filler; Frequencies; Hand; Health; Hour; Housing; Malignant Neoplasms; Missouri; Muscular Dystrophies; Process; Research; Research Personnel; Resources; Rodent; Targeted Research; Time; Universities; Work; animal care; base; endometriosis; human disease; medical schools; meetings

DESCRIPTION (provided by applicant): We request $500,000 to expand and renovate the cage wash area in the, University of Missouri-Columbia, and to purchase HEPA- filtered cage changing stations for use in the barrier portion of this vivarium. Targeted research faculty recruitment in the SOM, combined with a highly productive established research faculty, have created a critical need to house more rodents in the SOM vivarium. The holding capacity of this vivarium is currently limited not by space in the animal rooms but by the ability to process enough equipment through the cage wash area to meet required cage changing frequencies. Our current rack washer takes almost an hour to complete a cycle; we are limited to 9 loads during an 8-hour work day. Our existing bottle washer/filler has a capacity of 1 rack of bottles at a time and is configured so that it can only fill bottles used in conventional cages. Bottles for our ventilated racks must be filled by hand. Despite operating the cage wash 7 days a week for extended shifts, we cannot generate enough clean cages and accessories to support an increase in animal numbers in this vivarium. Expansion of the footprint of the cage wash area and installation of efficient and resource-conservative equipment will mitigate this problem. Purchase of HEPA-filtered changing stations to replace the horizontal laminar flow hoods in the barrier will protect the health of animal care staff and research personnel by greatly decreasing their exposure to airborne rodent allergens. Relevance: Animal-based research is essential to study human diseases such as diabetes, cancer, endometriosis, and muscular dystrophy.

描述（由申请人提供）：我们请求 500,000 美元来扩建和翻新密苏里大学哥伦比亚分校的笼子清洗区域，并购买 HEPA 过滤的笼子更换站，用于该动物园的屏障部分。 SOM 有针对性的研究人员招聘，加上高产的现有研究人员，迫切需要在 SOM 动物园中容纳更多的啮齿动物。目前，该动物园的容纳能力不仅受到动物房空间的限制，还受到通过笼子清洗区域处理足够设备以满足所需笼子更换频率的能力的限制。我们当前的架式清洗机需要近一个小时才能完成一个周期；每天 8 小时的工作日内，我们的载客量限制为 9 次。我们现有的洗瓶机/灌装机一次可容纳 1 架瓶子，其配置使其只能灌装传统笼中使用的瓶子。我们的通风架的瓶子必须手工填充。尽管每周 7 天进行笼子清洗以延长轮班时间，但我们无法生产足够的干净笼子和配件来支持该动物园中动物数量的增加。扩大网箱清洗区域的占地面积并安装高效且节约资源的设备将缓解这一问题。购买 HEPA 过滤的换尿布台来取代屏障中的水平层流罩，将大大减少动物护理人员和研究人员与空气中啮齿动物过敏原的接触，从而保护他们的健康。相关性：基于动物的研究对于研究糖尿病、癌症、子宫内膜异位症和肌肉萎缩症等人类疾病至关重要。