FASEB SRC on Protease in Hemostasis and Vascular Biology

FASEB SRC 关于蛋白酶在止血和血管生物学中的作用

基本信息

  • 批准号:
    8128143
  • 负责人:
  • 金额:
    $ 1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Partial support is requested for the "Proteases in Hemostasis and Vascular Biology" conference to be held under the auspices of the Summer Research Conference program of the Federation of American Societies for Experimental Biology (FASEB). This meeting will be the 10th in a series that has been held biennially since 1992 and is scheduled to be held at the FASEB summer conference site in Carefree, Arizona on June 12-17, 2011. The focus of the meeting has evolved from one originally devoted to structure-function studies of thrombin into a broader arena of proteases in hemostasis and vascular biology. Interest in this area has been exceptionally strong and research activity is accelerating based on new insights on the role of proteases and their receptors, substrates and inhibitors in hemostasis, vascular cell signaling, barrier function, embryonic development, bacterial virulence/host defense, and inflammatory diseases, including cardiovascular disease and neuroinflammatory disease. This unique conference has established itself in the field of proteases and vascular biology and enjoys an international reputation for consistently emphasizing unpublished, cutting-edge basic and translational research by investigators with diverse expertise and broad demographics. The meeting has routinely drawn together a powerful mix of premiere established investigators, outstanding young investigators and gifted trainees for intimate, balanced, highly-interactive and synergistic scientific exchanges. Some of the most spectacular recent achievements in the area of proteases in vascular biology were first unveiled at previous conferences and the collegial environment has routinely fostered important new research initiatives. The roster of invited speakers and discussion leaders who have already agreed to participate is impressive and include top investigators in the field. These attendees will enhance the stimulating nature of the environment for all attendees and especially junior investigators and trainees. As in past conferences, a priority of the organizers will be to promote program participation of women and minorities and facilitate attendance by junior faculty, students, postdoctoral fellows and individuals with physical disabilities. The program currently includes a keynote address and 9 sessions devoted to (1) platelet activation/regulation of thrombus formation, (2) biochemistry and cell biology of proteases and their receptors and inhibitors, (3) novel serine proteases and mechanisms coupling proteases to disease, (4) fXII- and fXI-dependent events in vivo, (5) protease signaling and vascular biology, (6) integrated systems controlling vascular permeability, (7) proteases in inflammation and host defense, (8) protease engineering and therapeutics, and (9) protease targets in neurobiology.
描述(由申请人提供):部分支持要求为“止血和血管生物学中的蛋白酶”会议将在美国实验生物学学会联合会(FASEB)夏季研究会议计划的主持下举行。这次会议将是自1992年以来每两年举行一次的系列会议中的第10次,定于2011年6月12日至17日在亚利桑那州无忧无虑的FASEB夏季会议现场举行。会议的重点已从最初致力于凝血酶的结构-功能研究发展到止血和血管生物学中蛋白酶的更广泛的竞技场。对这一领域的兴趣一直非常强烈,并且基于对蛋白酶及其受体,底物和抑制剂在止血,血管细胞信号传导,屏障功能,胚胎发育,细菌毒力/宿主防御和炎症性疾病(包括心血管疾病和神经炎症性疾病)中的作用的新见解,研究活动正在加速。这个独特的会议已经在蛋白酶和血管生物学领域确立了自己的地位,并因一贯强调具有不同专业知识和广泛人口统计学的研究人员的未发表,尖端的基础和转化研究而享有国际声誉。该会议定期吸引了一流的既定研究人员,杰出的年轻研究人员和有天赋的学员进行亲密,平衡,高度互动和协同的科学交流。最近在血管生物学蛋白酶领域取得的一些最引人注目的成就是在以前的会议上首次公布的,学院环境通常会促进重要的新研究计划。受邀发言者和已同意参加讨论的领导人名单令人印象深刻,其中包括实地的高级调查人员。这些与会者将提高所有与会者,特别是初级研究人员和学员的环境的刺激性。与过去的会议一样,组织者的优先事项将是促进妇女和少数民族的方案参与,并促进初级教师、学生、博士后研究员和身体残疾者的出席。该计划目前包括一个主题演讲和9个会议,致力于(1)血小板活化/血栓形成的调节,(2)蛋白酶及其受体和抑制剂的生物化学和细胞生物学,(3)新型丝氨酸蛋白酶和蛋白酶与疾病偶联的机制,(4)体内fXII和fXI依赖性事件,(5)蛋白酶信号传导和血管生物学,(6)控制血管通透性的集成系统,(7)炎症和宿主防御中的蛋白酶,(8)蛋白酶工程和治疗,以及(9)神经生物学中的蛋白酶靶标。

项目成果

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{{ truncateString('JAY L DEGEN', 18)}}的其他基金

Hemostatic factors and sickle cell disease
止血因素和镰状细胞病
  • 批准号:
    8256975
  • 财政年份:
    2012
  • 资助金额:
    $ 1万
  • 项目类别:
Hemostatic factors and sickle cell disease
止血因素和镰状细胞病
  • 批准号:
    8585089
  • 财政年份:
    2012
  • 资助金额:
    $ 1万
  • 项目类别:
Hemostatic factors and sickle cell disease
止血因素和镰状细胞病
  • 批准号:
    8403626
  • 财政年份:
    2012
  • 资助金额:
    $ 1万
  • 项目类别:
Thrombin-mediated proteolysis in neuroinflammatory disease
神经炎症疾病中凝血酶介导的蛋白水解作用
  • 批准号:
    8257519
  • 财政年份:
    2009
  • 资助金额:
    $ 1万
  • 项目类别:
Thrombin-mediated proteolysis in neuroinflammatory disease
神经炎症疾病中凝血酶介导的蛋白水解作用
  • 批准号:
    7750332
  • 财政年份:
    2009
  • 资助金额:
    $ 1万
  • 项目类别:
Thrombin-mediated proteolysis in neuroinflammatory disease
神经炎症疾病中凝血酶介导的蛋白水解作用
  • 批准号:
    8077297
  • 财政年份:
    2009
  • 资助金额:
    $ 1万
  • 项目类别:
Thrombin-mediated proteolysis in neuroinflammatory disease
神经炎症疾病中凝血酶介导的蛋白水解作用
  • 批准号:
    7903157
  • 财政年份:
    2009
  • 资助金额:
    $ 1万
  • 项目类别:
Hemostatic Factors as Determinants of Bacterial Virulence and Host Defense.
止血因素是细菌毒力和宿主防御的决定因素。
  • 批准号:
    7134328
  • 财政年份:
    2006
  • 资助金额:
    $ 1万
  • 项目类别:
Hemostatic Factors as Determinants of Bacterial Virulence and Host Defense
止血因素是细菌毒力和宿主防御的决定因素
  • 批准号:
    7650126
  • 财政年份:
    2006
  • 资助金额:
    $ 1万
  • 项目类别:
Hemostatic Factors as Determinants of Bacterial Virulence and Host Defense.
止血因素是细菌毒力和宿主防御的决定因素。
  • 批准号:
    7880724
  • 财政年份:
    2006
  • 资助金额:
    $ 1万
  • 项目类别:

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