2011 GLIAL BIOLOGY GRC

描述(由申请人提供)：本提案请求部分支持将于2011年3月6-11日在加利福尼亚州文图拉举行的国际神经胶质生物学会议，作为戈登研究会议系列的一部分。会议的广泛和长期目标是增加我们对神经胶质细胞在正常大脑功能和神经疾病期间相互作用以及与神经元相互作用的方式的理解。这次会议强调了星形胶质细胞和小胶质细胞的生物学，而不是少突胶质细胞的生物学。这次会议的具体目标是召集44名演讲者，在一个相对孤立的环境中，在为期五天的会议期间，与总共150名与会者讨论神经胶质研究的关键领域。该计划将有九个课程，广泛涉及神经胶质细胞参与突触结构和功能、突触发育、脑血流以及包括癫痫、阿尔茨海默病和ALS在内的一些神经疾病。此外，两个海报会议将允许所有与会者对这些主题的讨论作出贡献。这一应用的意义在于，戈登神经胶质生物学研究会议是定期召开的会议的重要组成部分，这些会议促进了全球对神经胶质细胞的研究，并帮助确定了需要实验解决的关键研究领域。这一应用与健康相关的是，神经胶质细胞参与了许多，可能是所有的神经系统疾病。对当前研究的讨论将促进我们对胶质细胞在健康和疾病中的理解。此外，在这次会议上的具体陈述将集中在神经胶质细胞参与大脑发育、癫痫、阿尔茨海默病、肌萎缩侧索硬化症和痛觉。 公共卫生相关性：这项应用的健康相关性是，神经胶质细胞参与了许多，可能是所有的神经系统疾病。对当前研究的讨论将促进我们对胶质细胞在健康和疾病中的理解。此外，在这次会议上的具体陈述将集中在神经胶质细胞参与大脑发育、癫痫、ALS、阿尔茨海默病、疼痛感知。通过帮助定义需要实验解决的关键问题，我们可以推进我们对神经胶质细胞如何参与神经疾病的理解，这是减轻这些疾病给社会带来的负担的必要第一步。 免责声明：请注意，以下批评是由评审员在研究小组会议之前准备的，基本上是以未经编辑的形式提供的。虽然审查员有机会根据小组的讨论更新或修订其书面评价，但不能保证在会议讨论之后更新了个别批评意见。因此，这些评论可能不能完全反映个别评审员在小组讨论结束时的最终意见或小组的最终多数意见。因此，讨论纪要和总结是审查员在会议上实际上认为至关重要的最后结论。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting on Glial Biology, as part of the Gordon Research Conference series, to be held in Ventura, California, March 6-11, 2011. The broad and long-term goal of the conference is to increase our understanding of the manner in which glial cells interact with one another and with neurons during normal brain function and in neurological diseases. The biology of astrocytes and microglial cells, more than that of oligodendrocytes, is emphasized in this meeting. The specific aim of this meeting will be to convene 44 speakers to discuss critical areas of glial research with a total of 150 participants, during a five-day conference in a relatively isolated setting. The program will have nine sessions that broadly address glia cell involvement in synaptic structure and function, synapse development, cerebral blood flow, and some neurological diseases including Epilepsy Alzheimer's disease and ALS. In addition, two poster sessions will permit all participants to contribute to discussion of these topics. The significance of this application is that the Gordon Research Conference on Glial Biology is an essential component of the recurring conferences that promote worldwide research on glial cells, and help define critical research areas in need of experimental resolution. The health relatedness of this application is that glial cells participate in many, possibly all, neurological diseases. Discussions about current research will advance our understanding of glial cells in both health and disease. In addition, specific presentations at this conference will focus on the involvement of glial cells in brain development, epilepsy, Alzheimer's disease, ALS, and pain perception. PUBLIC HEALTH RELEVANCE: The health relatedness of this application is that glial cells participate in many, possibly all, neurological diseases. Discussions about current research will advance our understanding of glial cells in both health and disease. In addition, specific presentations at this conference will focus on the involvement of glial cells in brain development, epilepsy, ALS, Alzheimer's disease, pain perception. By helping to define key questions that require experimental resolution we can advance our understanding of how glial cells are involved in neurological diseases, which is the first necessary step to lessening the burden of these diseases on society. Disclaimer: Please note that the following critiques were prepared by the reviewers prior to the Study Section meeting and are provided in an essentially unedited form. While there is opportunity for the reviewers to update or revise their written evaluation, based upon the group's discussion, there is no guarantee that individual critiques have been updated subsequent to the discussion at the meeting. Therefore, the critiques may not fully reflect the final opinions of the individual reviewers at the close of group discussion or the final majority opinion of the group. Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting.