FASEB SRC on Biology and Pathobiology of Kruppel-like Factors

FASEB SRC 关于 Kruppel 样因子的生物学和病理学

• 批准号: 8399296
• 负责人: JOYCE A. LLOYD
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8399296
• 关键词: Address; Antibodies; Area; Basic Science; Bioinformatics; Biology; Biophysics; California; Cardiology; Cardiovascular system; Cellular biology; Clinical Sciences; Collaborations; Development; Developmental Biology; Diabetes Mellitus; Differentiation and Growth; Discipline; Disease; Endocrinology; Family; Family member; Fellowship; Fostering; Functional disorder; Funding; Gastroenterology; Genetic; Goals; Grant; Heart Diseases; Hematology; Hepatology; Immune; Immune system; Inflammation; Inflammatory; International; Lead; Malignant Neoplasms; Molecular Biology; Mus; Obesity; Oral; Organ; Physiological; Physiological Processes; Physiology; Pluripotent Stem Cells; Process; Publications; Request for Applications; Research; Research Personnel; Role; Running; San Francisco; Science; Signal Transduction; Somatic Cell; Speed; System; Therapeutic; Time; Translational Research; Travel; United States National Institutes of Health; Universities; Zinc Fingers; abstracting; base; body system; career; career development; design; embryonic stem cell; erythroid Kruppel-like factor; human disease; innovation; interest; meetings; member; oncology; planetary Atmosphere; pluripotency; posters; programs; respiratory; stem cell biology; structural biology; symposium; therapeutic development; tool; transcription factor

DESCRIPTION (provided by applicant): This application requests funding in partial support of a 5-day FASEB Summer Research Conference (SRC) to be held in 2012, 2014 and 2016, entitled Biology and Pathobiology of Kruppel-Like Factors (KLFs). Kruppel- like factors are a family of zinc finger-containing transcription factors that represents a rapidly advancing field. Since the identification of the first member of this family, Erythroid Kruppel-Like Factor (EKLF or KLF1) 18 years ago, an additional 21 members have been identified. The study of the KLFs is an emerging area, with rapid increases in the number of NIH grants and publications in the past few years. Studies have indicated that KLFs exert important functions in diverse physiological processes involving the cardiovascular, digestive, respiratory, hematological and immune systems and in pathological states such as cancer, obesity, diabetes, and inflammatory conditions, among others. KLFs are also involved in the reprogramming of somatic cells to inducible pluripotent stem (iPS) cells and in maintaining the pluripotency of embryonic stem cells. These symposia are designed to bring together a group of international leaders in the field of KLF research with the goal of stimulating discussion and fostering collaboration. The potential for therapeutic development in cardiovascular, cancer, diabetes, and inflammatory diseases based on KLF biology is a distinct possibility that may result from the meeting. The SPECIFIC AIMS of the meeting are: 1. To provide a scientific program at the forefront of KLF research that is organized around the themes of physiological functions and organ-based pathophysiology of diseases. 2. To provide a venue for meaningful interchanges among investigators in the KLF field which foster interactions and potential collaborations in the basic, translational and clinicl sciences. 3. To provide a scientific platform with which to encourage active participation and career development of young investigators and trainees. PUBLIC HEALTH RELEVANCE: This application requests partial funding for an international conference on the Biology and Pathobiology of Kruppel-Like Factors (KLFs), a rapidly emerging field. KLF transcription factors are involved in numerous physiological processes in the cardiovascular, hematologic, immune, digestive and other systems. They also control pathophysiological processes including heart disease, inflammation, cancer, obesity, and diabetes. The conference is expected to stimulate scientific discussion and collaboration, and generate new ideas which will advance the field.

描述（由申请人提供）：本申请要求资助将于2012年，2014年和2016年举行的为期5天的FASEB夏季研究会议（SRC）的部分支持，题为Kruppel样因子（KLF）的生物学和病理学。Kruppel样因子是一个含锌指的转录因子家族，代表了一个快速发展的领域。自从鉴定出该家族的第一个成员以来，红系Kruppel样因子（EKLF或 KLF 1）18年前，又确定了21名成员。KLF的研究是一个新兴领域，在过去几年中，NIH的赠款和出版物数量迅速增加。研究表明，KLF在涉及心血管、消化、呼吸、血液和免疫系统的各种生理过程中以及在诸如癌症、肥胖、糖尿病和炎症状况等病理状态中发挥重要功能。KLF还参与体细胞重编程为诱导性多能干（iPS）细胞和维持胚胎干细胞的多能性。这些专题讨论会旨在汇集KLF研究领域的一批国际领导人，目的是激发讨论和促进合作。基于KLF生物学的心血管、癌症、糖尿病和炎性疾病的治疗开发潜力是会议可能产生的一种明显的可能性。会议的具体目标是：1。提供KLF研究前沿的科学计划，围绕生理功能和疾病的器官病理生理学主题组织。2.为KLF领域的研究人员提供有意义的交流场所，促进基础，转化和临床科学的互动和潜在合作。3.提供一个科学平台，鼓励年轻的调查人员和学员积极参与和职业发展。 公共卫生相关性：该申请要求为Kruppel样因子（KLF）的生物学和病理学国际会议提供部分资金，这是一个迅速兴起的领域。KLF转录因子参与心血管、血液、免疫、消化和其他系统中的许多生理过程。它们还控制病理生理过程，包括心脏病、炎症、癌症、肥胖和糖尿病。预计会议将激发科学讨论和合作，并产生推动该领域发展的新想法。