Oral Health in Breast Cancer Survivors on Aromatase Inhibitors

描述（由申请人提供）：芳香酶抑制剂（AIs）作为激素受体阳性乳腺癌绝经后妇女的常规辅助激素治疗。芳香化酶抑制及其严重的雌二醇（雌激素）耗竭，与低骨密度和骨质疏松症的风险增加以及骨折风险增加有关。AIs及其导致的激素消融对乳腺癌女性口腔健康和口腔健康相关生活质量的潜在影响尚不明确。一个项目将在密歇根大学多学科环境下进行。一项横断面研究将用于评估150名有早期乳腺癌病史接受辅助人工智能治疗的绝经后妇女和150名无癌症的绝经后妇女的口腔症状的患病率，这些妇女来自密歇根州东南部的密歇根大学卫生系统。全面的口腔检查（包括评估粘膜病变、牙周测量、龋齿、口腔x光、口腔液体和牙齿脱落检查）。评估社会人口和行为因素以及生活质量信息的问卷将被管理给所有参与者。逻辑回归模型将被用来分析关联的强度。本提案为Linda Susan Taichman博士在口腔健康领域的职业发展提供了一个全面的计划，因为它与辅助治疗和乳腺癌幸存者有关。短期目标是在以患者为中心的研究中获得临床研究专业技能，并获得内分泌治疗和口腔健康独立调查所需的辅助芳香酶抑制剂相关口服效应的知识。长期目标是通过制定旨在改善乳腺癌幸存者健康和保健的循证医师指导战略，加强医学教育与牙科之间的联系。教学培训和指导研究活动将为Taichman博士提供基础，她可以在该奖项的最后几年提交极具竞争力的资助申请，并开展未来的研究，以了解乳腺癌幸存者的最佳口腔护理。拟议的研究与NIDCR的使命有关，即发展有关癌症治疗对口腔健康相关影响的基础知识。最终，这些信息可以提高牙科健康专家和肿瘤学家预测和减轻人工智能治疗口腔毒性的能力。

DESCRIPTION (provided by applicant): Aromatase inhibitors (AIs) are routinely prescribed as adjuvant hormonal therapy for postmenopausal women with hormone receptor positive breast cancer. Aromatase inhibition with its profound estradiol (estrogen) depletion, is associated with an increased risk of low bone mineral density and osteoporosis with increased fracture risk. The potential impact of AIs and their resulting hormone ablation on oral health and oral health related quality of life in women with breast cancer is undefined. A project will be conducted at University of Michigan in a multidisciplinary environment. A cross-sectional study will be used to assess the prevalence of oral symptoms among 150 post-menopausal women with a history of early stage breast cancer receiving adjuvant AI therapy and 150 postmenopausal women without cancer recruited from the University of Michigan Health System in Southeastern Michigan. Comprehensive oral examinations (including assessment of mucosal lesions, periodontal measures, dental caries, oral x-rays, oral fluid, and tooth loss examination will be performed). Questionnaires assessing socio-demographic and behavioral factors as well as quality of life information will be administered to all participants. Logistic regression modeling will be used to analyze the strengths of associations as appropriate. This proposal provides a comprehensive plan for the career development of Dr. Linda Susan Taichman in the area of oral health as it pertains to adjuvant therapy and breast cancer survivorship. Short-term goals are to acquire skills in clinical research expertise in patient centered studies and to gain knowledge of adjuvant aromatase inhibitor related oral effects necessary for independent investigations of endocrine therapies and oral health. Long-term goals are to strengthen the linkage between Medical education and Dentistry by developing evidence-based physician guideline strategies aimed at improving the health and healthcare of breast cancer survivors. The didactic training and mentored research activities will provide Dr. Taichman with the foundation from which she can submit highly competitive grant applications in the final years of the award and develop future studies to understand optimal oral care for breast cancer survivors. The proposed research is relevant to that part of NIDCR's mission that pertains to developing fundamental knowledge concerning oral health related effects of cancer therapies. Ultimately, this information may improve the dental health professional's and the oncologist's ability to anticipate and mitigate oral toxicities from AI therapy.