Fundamental Mechanobiology of Tumor Progression

肿瘤进展的基础力学生物学

• 批准号: 8324742
• 负责人: Jan T. Liphardt
• 金额: $ 293.15万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-29 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324742
• 关键词: Area; Behavior; Biological Sciences; Cancer Biology; Cancer Control; Chemistry; Clinical Investigator; Development; Engineering; Environment; Goals; Institution; Knowledge; Laws; Malignant Neoplasms; Mathematics; Measurement; Physical Chemistry; Physics; Process; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Shapes; Testing; anticancer research; base; cancer therapy; innovation; interest; novel; physical science; programs; tumor progression

The goal of the PS-OC initiative is to collectively advance our understanding of the physical laws and principles that shape and govern the emergence of cancer and its behavior at ail scales. The PS-OCs will bring together expert teams from the fields of physics, cancer biology, physical chemistry, mathematics, and engineering to assemble and develop the infrastructure, capabilities, research programs, and the Network required to enable team research converging. the physical sciences with cancer biology. PS-OCs, individually and together, will support and nurture a new trans-disciplinary environment and research that: (1) originates and tests novel, non-traditional physical-sciences based approaches to understanding and controlling cancer; (2) generates orthogonal sets of physical measurements and integrates them with existing knowledge of cancer; and (3) develops and evaluates theoretical physics approaches to provide a comprehensive and dynamic picture of cancer. Ultimately, through coordinated, alternative, trans-Network development and testing of innovative, perhaps non-traditional, approaches to cancer processes, PS-OCs will catalyze and generate new bodies of knowledge and fields of cancer study that identify and define the critical aspects "physics, chemistry, and engineering" that operate at all levels in cancer processes. We are bringing together a cross section of investigators from the Physical and Life Sciences to participate in the center. This includes five Bay Area organizations with globally recognized and long-standing capabilities and interests in the physical sciences, engineering, and cancer research and treatment. We have also recruited clinical investigators from 2 outside institutions to compliment existing expertise and to extend the translational scope of our projects.

PS-OC计划的目标是共同推进我们对形成和控制癌症出现及其各种行为的物理定律和原理的理解。PS-OCs将汇集来自物理学、癌症生物学、物理化学、数学和工程领域的专家团队，以组装和开发基础设施、能力、研究计划和网络，使团队研究能够融合。物理科学与癌症生物学。PS-OCs，单独或共同，将支持和培育一个新的跨学科环境和研究：(1)发起和测试新颖的，非传统的物理科学为基础的方法来理解和控制癌症；(2)生成正交的物理测量集，并将其与现有的癌症知识进行整合；(3)发展和评估理论物理方法，以提供全面和动态的癌症图像。最终，通过协调，替代，跨网络开发和测试创新的，也许是非传统的，癌症过程的方法，PS-OCs将催化和产生新的知识体系和癌症研究领域，识别和定义在癌症过程的各个层面上运作的关键方面“物理，化学和工程”。我们汇集了来自物理和生命科学的研究人员来参与这个中心。这包括五家湾区组织，它们在物理科学、工程和癌症研究与治疗方面具有全球公认的长期能力和兴趣。我们还从两个外部机构招募了临床研究人员，以补充现有的专业知识并扩大我们项目的转化范围。