The Role of AGR2 in a Murine Model of Pancreatic Adenocarcinoma

AGR2 在小鼠胰腺癌模型中的作用

基本信息

  • 批准号:
    8290308
  • 负责人:
  • 金额:
    $ 22.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-07-01 至 2013-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Pancreatic adenocarcinoma is the fourth leading cause of cancer related death in the United States. Effective therapies currently do not exist. This application is based on the hypothesis that the AGR2 gene is essential for the formation or propagation of pancreatic cancer, and proposes to test the AGR2 gene's importance in a well-characterized animal model for pancreatic adenocarcinoma. The laboratory's previous work established that the AGR2 gene is actively expressed in all pancreatic adenocarcinomas. Additional studies using adenocarcinoma cell lines established that AGR2 promotes cell growth and features that are characteristic of metastasis. Because the initial experiments were performed in cell cultures grown in vitro, validation of AGR2's significance must be established in a whole animal. Recent advances in pancreatic cancer have produced several genetically engineered mouse models that closely reflect the development and progression of human pancreatic cancer. These models serve as a valuable resource to evaluate factors that influence the biology of pancreatic cancer. The K-ras gene is mutated in over 90% of pancreatic cancers. When the mutated K-ras gene is expressed in the mouse pancreas, early premalignant lesions similar to those observed in humans result. A small proportion of these lesions will progress to frank cancer. When a second mutation involving the p53 gene is added to the same mouse model, almost all of the mice will develop adenocarcinomas, of which many will also metastasize. This application proposes to examine whether the course of pancreatic adenocarcinoma is affected after genetically deleting the AGR2 gene in the two mouse models described. If the formation or propagation of premalignant lesions or cancer is successfully compromised by AGR2's absence, it would provide strong evidence of the gene's important role and provide a novel target for therapeutic intervention. This application represents a resubmission in which we provide additional data concerning the biologic relevance of the AGR2 gene to pancreatic cancer. In addition, we also provide data supporting our ability to produce the genetically defined mouse models as previously described.
描述(由申请人提供):胰腺腺癌是美国癌症相关死亡的第四大原因。目前还没有有效的治疗方法。本申请是基于AGR2基因对胰腺癌的形成或传播至关重要的假设,并提出在具有良好特征的胰腺腺癌动物模型中检验AGR2基因的重要性。该实验室之前的工作证实,AGR2基因在所有胰腺腺癌中都有活性表达。对腺癌细胞系的进一步研究证实,AGR2促进了细胞生长和转移的特征。由于最初的实验是在体外培养的细胞中进行的,因此必须在整个动物中验证AGR2的重要性。胰腺癌的最新进展已经产生了几种基因工程小鼠模型,这些模型密切反映了人类胰腺癌的发展和进展。这些模型为评估影响胰腺癌生物学的因素提供了宝贵的资源。K-ras基因在90%以上的胰腺癌中发生突变。当突变的K-ras基因在小鼠胰腺中表达时,就会产生与人类相似的早期癌前病变。这些病变中有一小部分会发展为癌症。当将涉及p53基因的第二个突变添加到同一小鼠模型中时,几乎所有的小鼠都会患上腺癌,其中许多还会转移。本申请旨在检测在上述两种小鼠模型中基因删除AGR2基因后是否会影响胰腺腺癌的病程。如果癌前病变或癌症的形成或传播被AGR2的缺失成功破坏,这将为该基因的重要作用提供强有力的证据,并为治疗干预提供新的靶点。该申请代表了我们提供关于AGR2基因与胰腺癌生物学相关性的额外数据的重新提交。此外,我们还提供数据支持我们的能力,以产生基因定义的小鼠模型,如前所述。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ANSON W LOWE其他文献

ANSON W LOWE的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ANSON W LOWE', 18)}}的其他基金

The Role of AGR2 in a Murine Model of Pancreatic Adenocarcinoma
AGR2 在小鼠胰腺癌模型中的作用
  • 批准号:
    8189795
  • 财政年份:
    2011
  • 资助金额:
    $ 22.12万
  • 项目类别:
Making a Digestive Sciences Career Palatable
让消化科学职业变得愉快
  • 批准号:
    7080384
  • 财政年份:
    2003
  • 资助金额:
    $ 22.12万
  • 项目类别:
Making a Digestive Sciences Career Palatable
让消化科学职业变得愉快
  • 批准号:
    7217961
  • 财政年份:
    2003
  • 资助金额:
    $ 22.12万
  • 项目类别:
Determinants of AGR2 effects in Barrett's esophagus and esophageal adenocarcinoma
Barrett 食管和食管腺癌中 AGR2 作用的决定因素
  • 批准号:
    7792335
  • 财政年份:
    2002
  • 资助金额:
    $ 22.12万
  • 项目类别:
Determinants of AGR2 effects in Barrett's esophagus and esophageal adenocarcinoma
Barrett 食管和食管腺癌中 AGR2 作用的决定因素
  • 批准号:
    7523291
  • 财政年份:
    2002
  • 资助金额:
    $ 22.12万
  • 项目类别:
Determinants of AGR2 effects in Barrett's esophagus and esophageal adenocarcinoma
Barrett 食管和食管腺癌中 AGR2 作用的决定因素
  • 批准号:
    8059699
  • 财政年份:
    2002
  • 资助金额:
    $ 22.12万
  • 项目类别:
Epithelial-Refluxate Interactions in Barrett's Esophagus
巴雷特食管上皮反流相互作用
  • 批准号:
    7114259
  • 财政年份:
    2002
  • 资助金额:
    $ 22.12万
  • 项目类别:
Epithelial-Refluxate Interactions in Barrett's Esophagus
巴雷特食管上皮反流相互作用
  • 批准号:
    6947280
  • 财政年份:
    2002
  • 资助金额:
    $ 22.12万
  • 项目类别:
Epithelial-Refluxate Interactions in Barrett's Esophagus
巴雷特食管上皮反流相互作用
  • 批准号:
    6787772
  • 财政年份:
    2002
  • 资助金额:
    $ 22.12万
  • 项目类别:
Determinants of AGR2 effects in Barrett's esophagus and esophageal adenocarcinoma
Barrett 食管和食管腺癌中 AGR2 作用的决定因素
  • 批准号:
    7633336
  • 财政年份:
    2002
  • 资助金额:
    $ 22.12万
  • 项目类别:

相似国自然基金

大肠癌发生机制的adenoma-adenocarcinoma pathway同serrated pathway的关系的研究
  • 批准号:
    30840003
  • 批准年份:
    2008
  • 资助金额:
    12.0 万元
  • 项目类别:
    专项基金项目

相似海外基金

Assessing The Impact of Heparanase and NDST2 Expression on Non-Small Cell Lung Adenocarcinoma Cell Motility
评估乙酰肝素酶和 NDST2 表达对非小细胞肺腺癌细胞运动的影响
  • 批准号:
    449570
  • 财政年份:
    2020
  • 资助金额:
    $ 22.12万
  • 项目类别:
    Studentship Programs
Analysis of cancer metastasis and invasion mechanism using a new lung adenocarcinoma cell line.
使用新的肺​​腺癌细胞系分析癌症转移和侵袭机制。
  • 批准号:
    16K10689
  • 财政年份:
    2016
  • 资助金额:
    $ 22.12万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Acquisition strategy of tumor-specific markers using established micropapillary pattern pulmonary adenocarcinoma cell line
使用已建立的微乳头模式肺腺癌细胞系获取肿瘤特异性标志物的策略
  • 批准号:
    26460441
  • 财政年份:
    2014
  • 资助金额:
    $ 22.12万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The antibetic drug metformin inhibits esophageal adenocarcinoma cell proliferation in vitro and in vivo.
抗生素药物二甲双胍在体外和体内抑制食管腺癌细胞增殖。
  • 批准号:
    25860540
  • 财政年份:
    2013
  • 资助金额:
    $ 22.12万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
The cell permeable peptide inhibits pancreatic ductal adenocarcinoma cell proliferations and can be used as the molecular targeting dru
细胞通透肽抑制胰腺导管腺癌细胞增殖,可作为分子靶向药物
  • 批准号:
    25461969
  • 财政年份:
    2013
  • 资助金额:
    $ 22.12万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Basic Research for elucidation of chemo-resistance in mucinous adenocarcinoma cell.
阐明粘液腺癌细胞化疗耐药性的基础研究。
  • 批准号:
    22791532
  • 财政年份:
    2010
  • 资助金额:
    $ 22.12万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
TAS::75 0849::TAS IN THIS PHASE I SBIR THE BREAST CANCER ADENOCARCINOMA CELL LI
TAS::75 0849::TAS 在这一阶段 I SBIR 乳腺癌腺癌细胞 LI
  • 批准号:
    8164743
  • 财政年份:
    2010
  • 资助金额:
    $ 22.12万
  • 项目类别:
Role of Endothelin-1 in osteoblastic bone metastasis produced by a human lung adenocarcinoma cell line
Endothelin-1 在人肺腺癌细胞系产生的成骨细胞骨转移中的作用
  • 批准号:
    19790127
  • 财政年份:
    2007
  • 资助金额:
    $ 22.12万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
CONNEXIN 43 EXPRESSION IN ADENOCARCINOMA CELL LINE
连接蛋白 43 在腺癌细胞系中的表达
  • 批准号:
    6972483
  • 财政年份:
    2004
  • 资助金额:
    $ 22.12万
  • 项目类别:
The mechanisms of highly metastetic capasity in highly metastatic subpopulations of lung adenocarcinoma cell line and these clinical applications
肺腺癌细胞系高转移亚群的高转移能力机制及临床应用
  • 批准号:
    15590831
  • 财政年份:
    2003
  • 资助金额:
    $ 22.12万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了