Histology

描述：组织学核心的总体目标是提供组织病理学服务，以便病理生理调查将得到定量形态学数据的支持。核心为组织学和细胞学分析提供专业知识和最先进的技术服务，所获得的数据以视觉和/或定量格式呈现。组织学核心是前一个周期中细胞、组织和成像核心的延续。Core已经提供了可靠的肺细胞和组织成像，并将在修订后的应用程序中继续提供这一基本服务。细胞和细胞成分可以很容易地可视化[例如，中性粒细胞、T细胞和巨噬细胞（及其颗粒）、胶原蛋白、弹性蛋白、毛细血管内皮细胞和周细胞以及基底膜]。核心还与组织病理学的新发展保持同步，并帮助参与的教师将适当的技术应用到他们的工作中

Description: The overall objective of the Histology Core is to provide histopathology services, so that pathophysiological invesfigafions will be backed by quantitative morphological data The Core provides expertise and state-of-the-art technical services for histologic and cytologic analyses, and the data obtained are presented in a visual and/or quantitative format. The Histology Core is a continuation ofthe Celt,Tissue, and Imaging Core in the previous cycle. The Core has provided reliable imaging of lung cells and tissues, and will continue to provide this essential service in the revised application. Cells and cell components can be easily visualized [e.g.,neutrophils, T cells, and macrophages (and their granules), collagen, elastin, capillary endothelial cells and pericytes, and basement membranes]. The Core also keeps abreast of new developments in histopathology and helps participating faculty apply the appropriate techniques to their research projects. Finally, the Core helps the project leaders prepare images for publication and presentation. It is important to emphasize that this Core's services extend far beyond those of just producing tissue sections. The Core provides knowledge, expertise and interpretation ofthe histological and cytological preparations produced. It helps the investigators evaluate and design experiments that use these techniques. It also trains investigators, postdoctoral fellows, graduate students and technicians in animal necropsy, Tissue fixafion, histopathology, immunohistochemistry, in situ hybridizafion, and image analysis. The Core staff can also provide assistance in the development of histopathologic and morphometric techniques as new findings make them necessary.