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Histology

组织学

基本信息

批准号：
8114349
负责人：
KATHLEEN Louise GABRIELSON
金额：
$ 19.48万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8114349
关键词：
American Animals Autopsy Back Basement membrane Blood Vessels Capillary Endothelial Cell Cell Count Cells Cellular Structures Chest Chronic Collagen Computer software Computers Cultured Cells Cybernetics Cytoplasmic Granules Data Data Analyses Development Elastin Electron Microscopy Enzymes Faculty Freezing Guidelines Histocytochemistry Histologic Histology Histopathology Image Image Analysis Immunohistochemistry In Situ In Situ Hybridization Individual Knowledge Lung Microscopy Morphology Paraffin Pathology Pericytes Policies Postdoctoral Fellow Preparation Procedures Protocols documentation Publications Publishing Research Personnel Research Project Grants Sampling Scientist Services Societies Specimen Staining method Stains T-Lymphocyte Techniques Tissues Visual Work Writing design graduate student image archival system investigator training light microscopy lung imaging macrophage meetings neutrophil research study

项目摘要

Description: The overall objective of the Histology Core is to provide histopathology services, so that pathophysiological invesfigafions will be backed by quantitative morphological data The Core provides expertise and state-of-the-art technical services for histologic and cytologic analyses, and the data obtained are presented in a visual and/or quantitative format. The Histology Core is a continuation ofthe Celt,Tissue, and Imaging Core in the previous cycle. The Core has provided reliable imaging of lung cells and tissues, and will continue to provide this essential service in the revised application. Cells and cell components can be easily visualized [e.g.,neutrophils, T cells, and macrophages (and their granules), collagen, elastin, capillary endothelial cells and pericytes, and basement membranes]. The Core also keeps abreast of new developments in histopathology and helps participating faculty apply the appropriate techniques to their research projects. Finally, the Core helps the project leaders prepare images for publication and presentation. It is important to emphasize that this Core's services extend far beyond those of just producing tissue sections. The Core provides knowledge, expertise and interpretation ofthe histological and cytological preparations produced. It helps the investigators evaluate and design experiments that use these techniques. It also trains investigators, postdoctoral fellows, graduate students and technicians in animal necropsy, Tissue fixafion, histopathology, immunohistochemistry, in situ hybridizafion, and image analysis. The Core staff can also provide assistance in the development of histopathologic and morphometric techniques as new findings make them necessary.

产品描述：组织学核心的总体目标是提供组织病理学服务，以便病理生理学研究将得到定量形态学数据的支持。核心为组织学和细胞学分析提供专业知识和最先进的技术服务，获得的数据以视觉和/或定量格式呈现。组织学核心是上一周期细胞、组织和成像核心的延续。Core提供了可靠的肺细胞和组织成像，并将在修订后的应用程序中继续提供这一基本服务。细胞和细胞组分可以容易地可视化[例如，中性粒细胞、T细胞和巨噬细胞（及其颗粒）、胶原蛋白、弹性蛋白、毛细血管内皮细胞和周细胞以及基底膜]。核心还跟上组织病理学的新发展，并帮助参与教师将适当的技术应用于他们的研究项目。最后，Core帮助项目负责人准备用于发布和演示的图像。重要的是要强调，该核心的服务远远超出了那些只是生产组织切片。核心提供组织学和细胞学制备的知识、专业知识和解释。它帮助研究人员评估和设计使用这些技术的实验。它还培训研究人员、博士后研究员、研究生和技术人员进行动物尸检、组织固定、组织病理学、免疫组织化学、原位杂交和图像分析。核心工作人员还可以在组织病理学和形态测量技术的发展方面提供援助，作为新的发现使它们成为必要。