Development of Clinical Trial Matching Engine Technology to Accelerate Participan

描述（由申请人提供）：开展和完成临床试验依赖于成功招募足够的患者志愿者，他们是任何给定研究的适当匹配。Corengi公司该公司开发了一个技术平台，支持一个专用网站，该网站具有匹配引擎和临床试验目录以及可由第三方在线嵌入的附带小部件。其目的是使个人能够迅速确定地理位置接近的试验，他们可能有资格参加这些试验。目前的重点是2型糖尿病（T2 D），但可以增强工具以涵盖其他疾病/病症。 加速临床试验参与者招募是一项重要的公共卫生目标， 在NIH SBIR综合征集中被NCRR称为感兴趣的研究课题。对于此SBIR第1阶段赠款，Corengi，Inc.建议创建新的类似临床试验匹配引擎。 第一个组成部分是确定3到5种疾病/病症，为这些疾病/病症创建匹配引擎的新临床试验。这将通过进行调查和访谈研究以及分析公共数据来实现。结果将用于确定最适合匹配引擎的特定疾病/状况。对clinicaltrials.gov上可用试验的分析也将有助于确定最佳候选人。 第二个组成部分是新的模拟匹配引擎的设计、编程和发布。这些努力将建立在Corengi团队在开发T2 D引擎方面的经验基础上。将为每种新引擎设计一份普通患者可以使用并有效过滤每种疾病/病症试验的医疗问卷。将为基于clinicaltrials.gov的试验信息开发新的数据导入流程，并对每项试验的标准tex进行数据挖掘和适当的算法编码。至此，新的匹配引擎将完成。 第三个组成部分是公开发布新的应用程序，分析由此产生的网站指标/用户响应，并确定商业化潜力。新闻稿、社交媒体整合以及搜索引擎和社交网络营销将用于提高对匹配工具的认识。关于新引擎的研究和反馈将与T2 D的初步工作相关联。 Corengi团队已经证明了其提供强大的T2 D临床试验匹配引擎的能力，该引擎受到在线糖尿病社区和受众的好评。该公司已成功地将这种产品商业化。基于该公司迄今为止的成功以及公众健康对患者志愿者招募以推进医学研究的持续需求，NIH将很好地为SBIR第1阶段拨款提案提供资金。 公共卫生相关性：Corengi，Inc.开发了一个技术平台，其目的是使个人能够快速识别地理上接近的试验， 合格的，支持一个专门的网站与匹配的引擎和临床试验目录和附带的小部件，可以嵌入在线由第三方。目前的重点是2型糖尿病，但这些工具可以得到加强，以涵盖其他疾病/病症。本项目提案旨在确定其他可能适合类似在线治疗的疾病/病症 资源，规划新的应用程序，并通过将更广泛的患者与临床研究联系起来，分析其对临床试验招募的影响。

DESCRIPTION (provided by applicant): Conducting and completing clinical trials relies on successful recruitment of enough patient volunteers, who are appropriate matches, for any given study. Corengi, Inc. has developed a technology platform that supports a dedicated website with a matching engine and clinical trials directory and accompanying widget that can be embedded online by third parties. The purpose is to enable individuals to quickly identify geographically close trials, which they may be qualified for. The current focus is on Type 2 diabetes (T2D) but the tools can be enhanced to cover other diseases/conditions. Accelerating participant recruitment for clinical trials is an important public health goal that is specifically called out as a research topic of interest by the NCRR in the NIH SBIR omnibus solicitation. For this SBIR Phase 1 grant, Corengi, Inc. proposes the creation of new analogous clinical trial matching engines. The first component is to identify 3 to 5 diseases/conditions for which to create new clinical trials matching engines. This will be done by conducting survey and interview research and analyzing public data. The results will be used to determine the specific diseases/conditions optimally suited for a matching engine. An analysis of the universe of available trials on clinicaltrials.gov will also help determine the best candidates. The second component is the design, programming, and release of the new analogous matching engines. These efforts will build upon the Corengi team's experience in their development of the T2D engine. A medical questionnaire that the average patient can use and is effective at filtering the trials for each disease/condition will be designed for each of the new engines. New data import processes for the clinicaltrials.gov-based trial information will be developed and the criteria tex for each trial will be data mined and the appropriate algorithms coded. At this point, the new matching engines will be completed. The third component is to publicly release the new applications, analyze the resultant website metrics/user responses, and determine the commercialization potential. Press releases, social media integration, and search engine and social network marketing will be used to increase awareness of the matching tools. Research and feedback about the new engines will be correlated with the initial work done with T2D. The Corengi team has already demonstrated its ability to deliver a powerful T2D clinical trial matching engine, which has been well received by online diabetes communities and audiences. The company has taken successful initial steps in commercializing this product. Based on the firm's success to date and the ongoing public health need for patient volunteer recruitment to advance medical research, the NIH would be well- served to fund this SBIR Phase 1 grant proposal. PUBLIC HEALTH RELEVANCE: Corengi, Inc. has developed a technology platform, whose purpose is to enable individuals to quickly identify geographically close trials, which they may be qualified for, that supports a dedicated website with a matching engine and clinical trials directory and accompanying widget that can be embedded online by third parties. The current focus is on Type 2 diabetes but the tools can be enhanced to cover other diseases/conditions. This project proposal is to identify other diseases/conditions that may be suited to similar online resources, program the new applications, and analyze their impact on clinical trials recruitment by connecting a broader range of patients with clinical research.