Modifying Dietary Behavior in Adolescents with Elevated Blood Pressure

改变血压升高青少年的饮食行为

• 批准号: 8217290
• 负责人: Sarah Collins Couch
• 金额: $ 37.83万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8217290
• 关键词: Accounting; Address; Adherence; Adolescence; Adolescent; Adult; Advocate; Affect; Aftercare; Age; Atherosclerosis; Attention; Behavior; Behavioral; Blood Pressure; Blood Vessels; Calories; Cardiac; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Caring; Child; Childhood; Clinic; Clinical; Clinical Markers; Clinical Trials; Counseling; Dairy Products; Data; Diagnosis; Diet; Diet Habits; Dietary Intervention; Dietary Practices; Dietary intake; Dietitian; Disease; Drops; Early treatment; Education; Epidemic; Essential Hypertension; Evaluation; Event; Fatty acid glycerol esters; Food; Frequencies; Future; Goals; Guidelines; Health; Heart; Hypertension; Hypotension; Incidence; Individual; Intake; Intervention; Life; Life Style; Link; Long-Term Effects; Mails; Measures; Methods; Monitor; Nutrient; Nutritional; Obesity; Outcome; Outcome Measure; Participant; Persons; Physical activity; Population; Prevalence; Prevention strategy; Preventive Intervention; Principal Investigator; Public Health; Randomized; Rare Diseases; Recommendation; Recruitment Activity; Relative (related person); Reporting; Research; Risk; Sample Size; Side; Site; Sodium; Staging; Suggestion; Teenagers; Telephone; Testing; Therapeutic; Treatment Protocols; Vascular System; Work; Youth; age group; base; clinical efficacy; design; effective therapy; experience; follow-up; food surveillance; fruits and vegetables; improved; meetings; multi-site trial; nutrition; nutrition education; pilot trial; population health; pre-clinical; prevent; primary outcome; programs; response; routine care; skills; treatment as usual; treatment strategy

DESCRIPTION (provided by applicant): Hypertension in youth is no longer a rare disease and the number of affected children and adolescents is growing with the evolving pediatric obesity epidemic in the US. Hypertension tracks from adolescence into adulthood and has been linked with preclinical indicators of adverse cardiovascular events in adults. Early prevention and intervention efforts are needed to address this increasing public and individual health problem. Preliminary studies from our research group demonstrate promising short-term effects of a behavioral nutrition intervention emphasizing a diet high in fruits, vegetables, and low fat dairy that is also low in fat and sodium (the DASH diet) on lowering blood pressure (BP) in adolescents. The purpose of this application is to extend these findings by examining the long term effects of an improved 24-week clinically-based behavioral nutrition intervention emphasizing the DASH diet (the DASH-4-Teens intervention) compared to routine nutrition care intervention on changing diet quality, BP, hypertension status, and vascular function in adolescents with elevated BP. The primary objectives of this study are two-fold: 1) to determine the impact of the intervention on dietary intake, BP, hypertension status, and vascular function immediately post-treatment and at 1 year follow-up, and 2) to examine the relationship between intervention adherence and diet, BP and vascular outcomes. Adolescents with diagnosed pre-hypertension and stage 1 hypertension will be randomly assigned to receive either the DASH-4-Teens intervention or routine nutrition care. The DASH-4-Teens intervention will include individual in-person nutrition counseling sessions, behavioral counseling telephone calls, and mailings. Routine nutrition care will include individual in-person counseling sessions on guidelines consistent with the Fourth Pediatric Report of the National High Blood Pressure Education Program. Primary outcomes will be measured in both conditions at 6 months (post-treatment) and at 1 year follow-up. Adherence to treatment will be measured as diet-related goals met, counseling session attendance, and telephone call and food monitoring completion. Findings are expected to improve the treatment of hypertensive adolescents in the clinical setting and contribute to the enhancement of the cardiovascular health of this population. Narrative: Hypertension can have deleterious effects on the cardiac and vascular systems in youth, yet there is a lack of proven effective treatment strategies for managing high blood pressure and restoring impaired cardiovascular function in early life. Strides in developing effective and generalizable treatment protocols for pediatric hypertension are urgently needed. A positive outcome from this clinical trial could have profound implications for future research and treatment recommendations for early intervention in managing primary hypertension.

描述（由申请人提供）：青少年高血压不再是一种罕见疾病，随着美国儿童肥胖流行病的不断发展，受影响的儿童和青少年人数正在增加。高血压从青春期到成年期，并与成人不良心血管事件的临床前指标有关。需要及早预防和干预，以解决这一日益严重的公共和个人健康问题。我们研究小组的初步研究表明，行为营养干预对降低青少年血压（BP）具有良好的短期影响，强调高水果，蔬菜和低脂乳制品的饮食，也是低脂肪和钠（DASH饮食）。本申请的目的是通过检查与常规营养护理干预相比，改善的24周临床行为营养干预（DASH-4-Teens干预）对改变BP升高青少年的饮食质量、BP、高血压状态和血管功能的长期影响来扩展这些发现。本研究的主要目的有两个：1）确定干预对治疗后即刻和1年随访时的饮食摄入、血压、高血压状态和血管功能的影响，2）检查干预依从性与饮食、血压和血管结局之间的关系。被诊断为高血压前期和1期高血压的青少年将被随机分配接受DASH-4-Teens干预或常规营养护理。DASH-4-青少年干预将包括个人面对面的营养咨询会议，行为咨询电话和邮件。常规营养护理将包括个人面对面的咨询会议，指导方针与国家高血压教育计划的第四次儿科报告一致。将在6个月（治疗后）和1年随访时测量两种情况下的主要结局。对治疗的依从性将根据饮食相关目标的实现、咨询会议的出席率以及电话和食物监测的完成情况来衡量。研究结果有望改善青少年高血压的临床治疗，并有助于提高这一人群的心血管健康。 叙述：高血压可能对年轻人的心脏和血管系统产生有害影响，但缺乏有效的治疗策略来管理高血压和恢复生命早期受损的心血管功能。迫切需要在开发有效和可推广的儿童高血压治疗方案方面取得进展。这项临床试验的积极结果可能对未来的研究和治疗原发性高血压的早期干预建议产生深远的影响。

项目成果

Predictive Modeling and Integrative Physiology: The Physiome Projects.

预测建模和综合生理学：生理组项目。

• DOI: 10.2174/1876536x01003010066
• 发表时间: 2010
• 期刊: The open pacing, electrophysiology & therapy journal
• 作者: Bassingthwaighte,JamesB

Dietary Approaches to Stop Hypertension Dietary Intervention Improves Blood Pressure and Vascular Health in Youth With Elevated Blood Pressure.

• DOI: 10.1161/hypertensionaha.120.16156
• 发表时间: 2021-01
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Couch SC;Saelens BE;Khoury PR;Dart KB;Hinn K;Mitsnefes MM;Daniels SR;Urbina EM
• 通讯作者: Urbina EM