PHYSIOLOGY CORE

生理学核心是YCCMD的核心组成部分，对中心的成功至关重要。的 核心由托马斯卡彭特博士指导，由三个亚单位组成。其中第一个， 组织学和组织形态计量学亚单位制备未脱钙组织切片， 骨染色和组织形态学分析。第二亚基，骨生化标志物 营业额提供测定骨钙素，骨特异性碱性磷酸酶，酒石酸抗性酸 磷酸酶、血清、P1NP和作为骨吸收标志物的1型胶原的C端肽（CTX）。 第三个亚单位，骨密度测定和成像提供pQCT，并与博士合作，目前是 建立了一个微型计算机断层扫描（uCT）设施，其特点是最近获得了一台Sampoo 35 uCT 扫描仪这些子单位作为独立但相互关联的组成部分，协同工作， 提供了一个全面的方法来分析广泛的动物模型。 生理学核心一直是该领域新的和初级研究人员的切入点， 大大提高了整个医学院和更大的中心成员的生产力 大学研究社区。核心利用包括来自内政部的研究人员 医学、矫形外科和康复、儿科、外科、妇产科、遗传学、细胞 生物学、免疫生物学、生物学、比较医学和血液学。我们的训练工作 更广泛的地理范围。 这一总体结构运作良好，我们将在下一个 融资周期。随着服务需求的增加和运营费用的持续增加， 不得不面对某些财政挑战。我们的成本回收计划使我们能够以 9年来，预算平衡。此外，通过有效的管理，我们保持了充分的 适度的收费结构，以限制费率的增加，从而尽量减少对初级和首次 investigators.

The Physiology Core is a central component of the YCCMD and critical to the success of the Center. The Core is directed by Dr. Thomas Carpenter, and is comprised of three subunits. The first of these, the Histology and Histomorphometry subunit prepares undecalcified tissue sections and performs specialized staining of bone and histomorphpmetric analyses. The second subunit, Biochemical Markers of Bone Turnover offers assays for osteocalcin, bone specific alkaline phosphatase, tartrate resistant acid phosphatase, serum, P1NP, and the C-telopeptide of type 1 collagen (CTX) as a bone resorption marker. The third subunit, Bone Densitometry and Imaging offers pQCT and, in collaboration with Dr. is currently establishing a micro-computed tomographic (uCT) facility featuring a recently acquired Scanco 35 uCT scanner. These subunits, functioning as separate but interrelated components, work synergistically to provide a comprehensive approach to analyzing a wide range of animal models. The Physiology Core has been a focal point of entry for new and junior investigators in the field, and has greatly enhanced the productivity of Center members throughout the Medical School and in the larger University research community. Core utilization has included researchers from the Departments of Internal Medicine, Orthopaedics and Rehabilitation, Pediatrics, Surgery, Obstetrics and Gynecology, Genetics, Cell Biology, Immunobiology, Biology, Comparative Medicine, and Hematology. Our training efforts have had an even broader geographic reach. This overall structure has worked well and we will maintain the described organizational format for the next funding cycle. With increased demands for services and the invariable increase in operating expenses, we have had to meet certain fiscal challenges. Our cost recovery program has allowed us to operate with a balanced budget for 9 years. Moreover, with efficient management we have maintained a sufficiently modest fee structure as to limit rate increases, thereby minimizing the impact on junior and first time investigators.