Training in Muscle Biology and Muscle Disease
肌肉生物学和肌肉疾病培训
基本信息
- 批准号:8253710
- 负责人:
- 金额:$ 24.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-05-01 至 2016-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The muscle community at the University of Pennsylvania has established an outstanding training program in Muscle Biology and Muscle Disease, supported in part by the T32 mechanism. Members of the Penn community are known world-wide for excellence in muscle research, and this program facilitates collaborative training opportunities for predoctoral students and postdoctoral fellows. Our training program enables trainees to work in laboratories directed by principal investigators who are leaders in the study of the cell biology, genetics, physiology, and/or pathology of muscle. Although the range of interests and expertise of the trainers on this grant is broad, the training is focused on elucidating the mechanisms of muscle function and disease. The program is designed to take advantage of the highly collaborative nature of the faculty, thus providing the trainees with the opportunity to integrate molecular and clinical aspects of muscle biology into their research. Trainees will also take advantage of our intimate connections with the Wellstone Muscular Dystrophy Cooperative Research Center training and education core based at Penn. Through this core, our trainees will receive education in the physiological and clinical aspects of muscular dystrophy. This training diversity provides an unparalleled training environment in the area of muscle biology. This is evidenced by the many prominent scientists around the world who have trained in this field at the University of Pennsylvania.
描述(由申请人提供):宾夕法尼亚大学肌肉界在肌肉生物学和肌肉疾病方面建立了一个杰出的训练计划,部分由T32机制支持。宾夕法尼亚大学社区成员在肌肉研究方面的卓越表现举世闻名,这个项目为博士生和博士后提供了合作培训的机会。我们的培训计划使受训者能够在主要研究人员的实验室工作,这些研究人员是肌肉细胞生物学、遗传学、生理学和/或病理学的领导者。尽管培训师的兴趣和专业知识范围很广,但培训的重点是阐明肌肉功能和疾病的机制。该计划旨在利用教师的高度协作性,从而为学员提供将肌肉生物学的分子和临床方面整合到他们的研究中的机会。学员还将利用我们与宾夕法尼亚大学威尔斯通肌肉萎缩症合作研究中心培训和教育核心的密切联系。通过这个核心,我们的学员将接受肌肉萎缩症的生理和临床方面的教育。这种训练的多样性为肌肉生物学领域提供了一个无与伦比的训练环境。世界上许多在宾夕法尼亚大学接受过这一领域训练的杰出科学家证明了这一点。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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E. Michael Ostap其他文献
Biochemical and Functional Characterization of the Interaction of Myo1c with 14-3-3
- DOI:
10.1016/j.bpj.2017.11.1790 - 发表时间:
2018-02-02 - 期刊:
- 影响因子:
- 作者:
Huan-Hong Ji;E. Michael Ostap - 通讯作者:
E. Michael Ostap
Buffer Exchange while Probing a Single Actomyosin Interaction in the Optical Trap
- DOI:
10.1016/j.bpj.2019.11.2445 - 发表时间:
2020-02-07 - 期刊:
- 影响因子:
- 作者:
Aaron Snoberger;Donald A. Winkelmann;E. Michael Ostap;Yale E. Goldman - 通讯作者:
Yale E. Goldman
Force Generation by Membrane-Bound Myo1c, a Single Molecule Study
- DOI:
10.1016/j.bpj.2012.11.3547 - 发表时间:
2013-01-29 - 期刊:
- 影响因子:
- 作者:
Serapion Pyrpassopoulos;Henry Shuman;E. Michael Ostap - 通讯作者:
E. Michael Ostap
Beta-Cardiac Myosin with an HCM Mutation (R712L) has an Inhibited Working Stroke that is Rescued by the Drug Omecamtiv Mecarbil
- DOI:
10.1016/j.bpj.2019.11.1082 - 发表时间:
2020-02-07 - 期刊:
- 影响因子:
- 作者:
Aaron Snoberger;Bipasha Barua;Jennifer L. Atherton;Eva Forgacs;Yale E. Goldman;Donald A. Winkelmann;E. Michael Ostap - 通讯作者:
E. Michael Ostap
Single Molecule, Optical Trapping Studies of Omecamtiv Mercarbil on Human Cardiac Myosin's Force Production
- DOI:
10.1016/j.bpj.2017.11.1787 - 发表时间:
2018-02-02 - 期刊:
- 影响因子:
- 作者:
Michael S. Woody;Michael J. Greenberg;Bipasha Barua;Donald A. Winkelmann;Yale E. Goldman;E. Michael Ostap - 通讯作者:
E. Michael Ostap
E. Michael Ostap的其他文献
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{{ truncateString('E. Michael Ostap', 18)}}的其他基金
2014 Muscle and Molecular Motors Gordon Research Conference
2014年肌肉与分子马达戈登研究会议
- 批准号:
8714731 - 财政年份:2014
- 资助金额:
$ 24.57万 - 项目类别:
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