Non-Invasive Radio-Frequency Field Induced Therapy Destruction of Malignant Cells

项目2将探索与原发性肝肿瘤(肝细胞癌)进展动力学相关的问题，加深对基于射频(RF)的热疗和使用金纳米颗粒(AuNPs)和富勒烯颗粒(Nano-C60)的肝细胞癌的MRI/CT成像所涉及的生物物理屏障的了解。这些将包括纳米颗粒向病变的传输；纳米颗粒在肿瘤细胞内的充分和特定的积聚；射频激活时产生的热以及向周围组织的热传递。这一目标将通过体外测试和体内研究与预测性的硅内数学模型相结合的综合过程来实现。领导该项目的团队汇集了多学科的专业知识，由史蒂文·A·柯利博士和朗·威尔逊博士共同领导，保罗·切鲁库里博士担任联合研究员。柯利博士是MDACC的外科肿瘤学教授和莱斯大学的机械工程和材料科学教授。威尔逊博士在莱斯大学担任化学教授已有30多年。他曾获得NSF和NIH赞助的奖学金，并出版了150多篇手稿和书籍章节。Cherukuri博士是MDACC外科肿瘤学和实验治疗学系的助理教授，在诺贝尔奖获得者理查德·E·斯莫利教授和赖斯大学布鲁斯·魏斯曼教授的指导下获得了物理化学博士学位。Cherukuri博士的研究重点是用于治疗癌症和心脏病的纳米级诊断和治疗材料的合成、表征和开发。

PROJECT 2 will explore issues related to the progression kinetics of a primary hepatic tumor (hepatocellular carcinoma), developing a broader understanding of the biophysical barriers involved in the Radio Frequency (RF) based thermal therapy and MRI/CT imaging of HCC employing gold nanoparticles (AuNPs) and fullerene particles (nano-C60). These will include the transport of the nanoparticles towards the lesion; the sufficient and specific accumulation of the nanoparticles within the tumor cells; the heat generation upon RF activation and the heat transfer to the surrounding tissue. This goal will be achieved through an integrated process where in-vitro testing and in-vivo studies are combined with predictive in-silico mathematical models. The Team leading this project brings together a multidisciplinary expertise and is composed of Dr. Steven A. Curley and Dr. Lon Wilson as co-leaders and Dr. Paul Cherukuri as co-investigator. Dr. Curley is a Professor of Surgical Oncology at the MDACC and Professor of Mechanical Engineering and Materials Science at Rice University. Dr. Wilson has been a Professor of Chemistry at Rice University for over 30 years. He has held NSF and NIH-sponsored fellowships and has published over 150 manuscripts and book chapters. Dr. Cherukuri is an Assistant Professor within the Surgical Oncology and Experimental Therapeutics Department of the MDACC and received his Ph.D. in physical chemistry under the supervision of Nobel Laureate, Prof. Richard E. Smalley and Prof. Bruce Weisman at Rice University. Dr. Cherukuri's research focused on the synthesis, characterization and development of nanoscale diagnostic and therapeutic materials for the treatment of cancer and heart disease.