Yale Clinical Neuroscientist Training Program

耶鲁大学临床神经科学家培训计划

基本信息

  • 批准号:
    8331031
  • 负责人:
  • 金额:
    $ 7.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-03-01 至 2017-02-28
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This proposal describes the Clinical Neuroscientist Training Program (CNSTP), the research education program for Neurology residents at the Yale School of Medicine. This program integrates the vast array of innovative and exciting collaborative research opportunities available within the School of Medicine with a select group of outstanding, dedicated mentors in neuroscience. These mentors were selected on the basis of significant research accomplishments, a consistent record of independent funding, and an exceptional track record in the mentoring of clinician scientists. This group of mentors, when combined with the vibrant neuroscience community at Yale, a track record of training distinguished clinicians, rich core facilities and resources, makes the CNSTP at Yale a unique program that develops the careers of physician-scientists. Since 2008, this program already has an established track record of nurturing careers of neurology residents towards career development awards. The present application leverages these existing strengths and institutionalizes them with an executive committee and formal oversight and evaluations, and seeks NINDS funding to buttress these efforts. PUBLIC HEALTH RELEVANCE: Nationally, there is a pressing need for highly trained clinician-scientists working towards understanding basic mechanisms of diseases of the brain. The Yale Clinical Neuroscientist Training Program (CNSTP) is uniquely designed to provide the research tools, clinical skills, and mentorship required in the transition from resident to independent faculty member. Many residents in Neurology come to Yale with an extensive research background and they complete residency as highly skilled neurologists equipped with state-of-the-art knowledge of neuroscience and neurological disease. They also leave residency with a keen grasp of the most pressing unanswered questions in nervous system disease. This program will allow them to transition back to the laboratory using the vast resources at Yale to combine their background in neuroscience research with their newly developed keen understanding of the state of knowledge of neurological disease into a basic, clinical and/or translational research project. The goal will be harness research conducted during this program to compete for a mentored career award and ultimately an independently funded research career. We are confident that these carefully trained and nurtured individuals will develop into leaders in academic medicine that will train the next generation of top-flight clinician scientists
描述(由申请人提供):本提案描述了临床神经科学家培训计划(CNSTP),这是耶鲁医学院为神经学住院医师提供的研究教育计划。这一计划结合了医学院内可用的大量创新和令人兴奋的合作研究机会,以及一批杰出的、专注于神经科学的导师。这些导师是根据重要的研究成就、独立资助的一贯记录以及指导临床医生科学家的杰出记录来选择的。这群导师与耶鲁充满活力的神经科学社区、培训杰出临床医生的记录、丰富的核心设施和资源相结合,使耶鲁的CNSTP成为一个发展内科科学家职业生涯的独特项目。自2008年以来,该计划已经建立了培养神经科住院医生的职业生涯以获得职业发展奖的记录。本申请利用了这些现有的优势,并通过执行委员会和正式监督和评价将其制度化,并寻求国家开发计划的资金来支持这些努力。 与公共卫生相关:在全国范围内,迫切需要训练有素的临床医生和科学家致力于了解大脑疾病的基本机制。耶鲁临床神经科学家培训计划(CNSTP)是专门设计的,旨在提供从住院医师过渡到独立教员所需的研究工具、临床技能和指导。许多神经病学的住院医生来到耶鲁大学,拥有广泛的研究背景,他们作为高技能的神经科医生完成实习,配备了最先进的神经科学和神经疾病知识。他们还对神经系统疾病中最紧迫的悬而未决的问题有了敏锐的把握。这项计划将使他们能够利用耶鲁的大量资源重新回到实验室,将他们在神经科学研究方面的背景与他们对神经系统疾病知识状况的新发展的敏锐理解结合在一起,形成一个基础、临床和/或转化性研究项目。目标将是利用在该计划期间进行的研究,以竞争指导职业奖项,并最终获得独立资助的研究职业。我们相信,这些经过精心训练和培养的人将发展成为学术医学的领导者,培养下一代一流的临床医生科学家。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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David A. Hafler其他文献

Increased IL-12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand
进行性多发性硬化症中 IL-12 的产生增加:通过 CD40 配体诱导活化的 CD4 T 细胞
  • DOI:
    10.1177/135245859600200519
  • 发表时间:
    1996
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Howard L. Weiner;Konstantin E. Balashov;Derek R. Smith;Samia J. Khoury;David A. Hafler
  • 通讯作者:
    David A. Hafler
Insulin auto-antigenicity in type 1 diabetes (Reply)
1 型糖尿病中的胰岛素自身抗原性(回复)
  • DOI:
    10.1038/nature04424
  • 发表时间:
    2005-11-23
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    David A. Hafler;Sally C. Kent;Yahua Chen;Lisa Bregoli;Sue M. Clemmings;Bernhard Hering;Norma Sue Kenyon;Camillo Ricordi
  • 通讯作者:
    Camillo Ricordi
FOXP3+ regulatory T cells in the human immune system
人类免疫系统中的 FOXP3+调节性 T 细胞
  • DOI:
    10.1038/nri2785
  • 发表时间:
    2010-06-18
  • 期刊:
  • 影响因子:
    60.900
  • 作者:
    Shimon Sakaguchi;Makoto Miyara;Cristina M. Costantino;David A. Hafler
  • 通讯作者:
    David A. Hafler
Antigen-driven peripheral immune tolerance. Suppression of organ-specific autoimmune diseases by oral administration of autoantigens.
抗原驱动的外周免疫耐受。
  • DOI:
    10.1007/978-3-642-51479-1_81
  • 发表时间:
    1991
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Howard L. Weiner;Howard L. Weiner;Howard L. Weiner;Ariel Miller;Ariel Miller;Ariel Miller;Samia J. Khoury;Samia J. Khoury;Samia J. Khoury;Z. J. Zhang;Z. J. Zhang;Z. J. Zhang;Ahmad Al;Ahmad Al;Ahmad Al;Stanley A. Brod;Stanley A. Brod;Stanley A. Brod;Ofer Lider;Ofer Lider;Ofer Lider;Paul A. T. Higgins;Paul A. T. Higgins;Paul A. T. Higgins;Raymond A. Sobel;Raymond A. Sobel;Raymond A. Sobel;Makoto Matsui;Makoto Matsui;Makoto Matsui;Mohamed H. Sayegh;Mohamed H. Sayegh;Mohamed H. Sayegh;Charles C. J. Carpenter;Charles C. J. Carpenter;Charles C. J. Carpenter;George Eisenbarth;George Eisenbarth;George Eisenbarth;R. Nussenblatt;R. Nussenblatt;R. Nussenblatt;David A. Hafler;David A. Hafler;David A. Hafler
  • 通讯作者:
    David A. Hafler
Functional Characterization of Autoreactive T-cells in Acute Disseminated Encephalomyelitis 199
急性播散性脑脊髓炎中自身反应性 T 细胞的功能特征 199
  • DOI:
    10.1203/00006450-199609000-00222
  • 发表时间:
    1996-09-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Annette Pohi-Koppe;Sandra K. Burchett;David A. Hafler
  • 通讯作者:
    David A. Hafler

David A. Hafler的其他文献

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{{ truncateString('David A. Hafler', 18)}}的其他基金

Targeting T cell dysfunction in glioblastoma: A proof-of-concept Phase 0/I trial of anti-TIGIT antibody AB154 in combination with anti-PD1 antibody AB122
靶向胶质母细胞瘤中的 T 细胞功能障碍:抗 TIGIT 抗体 AB154 与抗 PD1 抗体 AB122 联合的概念验证 0/I 期试验
  • 批准号:
    10346649
  • 财政年份:
    2022
  • 资助金额:
    $ 7.56万
  • 项目类别:
Targeting T cell dysfunction in glioblastoma: A proof-of-concept Phase 0/I trial of anti-TIGIT antibody AB154 in combination with anti-PD1 antibody AB122
靶向胶质母细胞瘤中的 T 细胞功能障碍:抗 TIGIT 抗体 AB154 与抗 PD1 抗体 AB122 联合的概念验证 0/I 期试验
  • 批准号:
    10573141
  • 财政年份:
    2022
  • 资助金额:
    $ 7.56万
  • 项目类别:
Systems Immune Profiling of Divergent Responses to Infection
对感染的不同反应的系统免疫分析
  • 批准号:
    10265709
  • 财政年份:
    2020
  • 资助金额:
    $ 7.56万
  • 项目类别:
Systems Immune Profiling of Divergent Responses to Infection
对感染的不同反应的系统免疫分析
  • 批准号:
    10205567
  • 财政年份:
    2020
  • 资助金额:
    $ 7.56万
  • 项目类别:
COVID-19 Supplement: Systems Immune Profiling of Divergent Responses to Infection
COVID-19 补充:对感染的不同反应的系统免疫分析
  • 批准号:
    10265708
  • 财政年份:
    2020
  • 资助金额:
    $ 7.56万
  • 项目类别:
Immunophenotyping for COVID-19 Cohort (IMPACC)
COVID-19 队列的免疫表型分析 (IMPACC)
  • 批准号:
    10265706
  • 财政年份:
    2020
  • 资助金额:
    $ 7.56万
  • 项目类别:
Core for COVID-19 Cohort IMPACC
COVID-19 队列 IMPACC 核心
  • 批准号:
    10265707
  • 财政年份:
    2020
  • 资助金额:
    $ 7.56万
  • 项目类别:
Yale Clinical Neuroscientist Training Program
耶鲁大学临床神经科学家培训计划
  • 批准号:
    10333938
  • 财政年份:
    2012
  • 资助金额:
    $ 7.56万
  • 项目类别:
Yale Clinical Neuroscientist Training Program
耶鲁大学临床神经科学家培训计划
  • 批准号:
    10210303
  • 财政年份:
    2012
  • 资助金额:
    $ 7.56万
  • 项目类别:
The role of the innate immune system on Treg reprogramming in human autoimmune di
先天免疫系统在人类自身免疫性疾病中 Treg 重编程中的作用
  • 批准号:
    8495933
  • 财政年份:
    2012
  • 资助金额:
    $ 7.56万
  • 项目类别:

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