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中文摘要
翻译
描述(由申请人提供):本提案描述了临床神经科学家培训计划(CNSTP),耶鲁大学医学院神经病学住院医师的研究教育计划。该计划将医学院内提供的大量创新和令人兴奋的合作研究机会与一组优秀的,专注的神经科学导师相结合。这些导师是根据重大的研究成就,独立资助的一致记录,以及临床科学家指导的特殊记录而选择的。这群导师,当与耶鲁大学充满活力的神经科学社区,培训杰出的临床医生,丰富的核心设施和资源的跟踪记录相结合时,使耶鲁大学的CNSTP成为发展医生科学家职业生涯的独特计划。自2008年以来,该计划已经建立了培养神经病学住院医师职业生涯的记录,以获得职业发展奖。本申请利用这些现有的优势,并通过执行委员会和正式的监督和评估将其制度化,并寻求NINDS资金来支持这些努力。 公共卫生相关性:在全国范围内,迫切需要训练有素的临床科学家致力于了解大脑疾病的基本机制。耶鲁大学临床神经科学家培训计划(CNSTP)是独特的设计,以提供从居民到独立教师的过渡所需的研究工具,临床技能和指导。神经病学的许多居民来到耶鲁大学有着广泛的研究背景,他们完成居住作为高度熟练的神经学家配备了神经科学和神经疾病的最先进的知识。他们也离开居住与神经系统疾病最紧迫的悬而未决的问题敏锐的把握。该计划将允许他们使用耶鲁大学的大量资源过渡回实验室,将他们在神经科学研究方面的背景与他们对神经疾病知识状态的新发展的敏锐理解结合起来,以联合收割机进行基础,临床和/或转化研究项目。我们的目标将是利用在此计划期间进行的研究,以竞争一个指导的职业奖,并最终独立资助的研究生涯。我们相信,这些精心训练和培养的个人将发展成为学术医学的领导者,将培养下一代一流的临床科学家
英文摘要
DESCRIPTION (provided by applicant): This proposal describes the Clinical Neuroscientist Training Program (CNSTP), the research education program for Neurology residents at the Yale School of Medicine. This program integrates the vast array of innovative and exciting collaborative research opportunities available within the School of Medicine with a select group of outstanding, dedicated mentors in neuroscience. These mentors were selected on the basis of significant research accomplishments, a consistent record of independent funding, and an exceptional track record in the mentoring of clinician scientists. This group of mentors, when combined with the vibrant neuroscience community at Yale, a track record of training distinguished clinicians, rich core facilities and resources, makes the CNSTP at Yale a unique program that develops the careers of physician-scientists. Since 2008, this program already has an established track record of nurturing careers of neurology residents towards career development awards. The present application leverages these existing strengths and institutionalizes them with an executive committee and formal oversight and evaluations, and seeks NINDS funding to buttress these efforts. PUBLIC HEALTH RELEVANCE: Nationally, there is a pressing need for highly trained clinician-scientists working towards understanding basic mechanisms of diseases of the brain. The Yale Clinical Neuroscientist Training Program (CNSTP) is uniquely designed to provide the research tools, clinical skills, and mentorship required in the transition from resident to independent faculty member. Many residents in Neurology come to Yale with an extensive research background and they complete residency as highly skilled neurologists equipped with state-of-the-art knowledge of neuroscience and neurological disease. They also leave residency with a keen grasp of the most pressing unanswered questions in nervous system disease. This program will allow them to transition back to the laboratory using the vast resources at Yale to combine their background in neuroscience research with their newly developed keen understanding of the state of knowledge of neurological disease into a basic, clinical and/or translational research project. The goal will be harness research conducted during this program to compete for a mentored career award and ultimately an independently funded research career. We are confident that these carefully trained and nurtured individuals will develop into leaders in academic medicine that will train the next generation of top-flight clinician scientists
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Targeting T cell dysfunction in glioblastoma: A proof-of-concept Phase 0/I trial of anti-TIGIT antibody AB154 in combination with anti-PD1 antibody AB122
  • 批准号:
    10346649
  • 项目类别:
  • 资助金额:
    $69.51万
  • 财政年份:
    2022
  • 负责人:
    David A. Hafler
  • 依托单位:
Targeting T cell dysfunction in glioblastoma: A proof-of-concept Phase 0/I trial of anti-TIGIT antibody AB154 in combination with anti-PD1 antibody AB122
  • 批准号:
    10573141
  • 项目类别:
  • 资助金额:
    $67.34万
  • 财政年份:
    2022
  • 负责人:
    David A. Hafler
  • 依托单位:
Systems Immune Profiling of Divergent Responses to Infection
  • 批准号:
    10265709
  • 项目类别:
  • 资助金额:
    $107.73万
  • 财政年份:
    2020
  • 负责人:
    David A. Hafler
  • 依托单位:
Systems Immune Profiling of Divergent Responses to Infection
  • 批准号:
    10205567
  • 项目类别:
  • 资助金额:
    $45.42万
  • 财政年份:
    2020
  • 负责人:
    David A. Hafler
  • 依托单位:
国内基金
海外基金
患者依从性与脑卒中后跌倒风险相关性及“Teach-Back ”护理干预效应研究
  • 批准号:
    2026JJ81464
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    叶婷
  • 依托单位:
基于Teach-back药学科普模式的慢阻肺患者吸入用药依从性及疗效研究
  • 批准号:
    2024KP61
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    余丹
  • 依托单位:
离散型超导磁体的加热线诱发Quench-Back效应及调控技术研究
  • 批准号:
    12405188
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30.00万元
  • 批准年份:
    2024
  • 负责人:
    童玉锦
  • 依托单位:
基于Quench-Back保护的超导螺线管磁体失超过程数值模拟研究
  • 批准号:
    51307073
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    25.0万元
  • 批准年份:
    2013
  • 负责人:
    郭兴龙
  • 依托单位: