2012 Biology of Acute Respiratory Infection Gordon Research Conference

说明： 这项申请要求提供资金，以部分支持戈登急性呼吸道感染生物学研究会议第三次会议。本次会议将于2012年3月11日至16日在加利福尼亚州文图拉举行，我们预计将有110至150名科学家参加。这次多学科会议的首要目标是提供一个展示和讨论在急性肺部感染领域的杰出研究的环境。由于感染肺部的不同病原体激活了有限数量的保守免疫反应，因此有大量信息可以由在不同病原体工作的同事和研究不同病原体的同事共享。疫苗开发的一般原则，特别是激活局部免疫保护与许多不同类型的肺部感染高度相关。会议将持续4天半，每天早上都会发表演讲，讨论与不同类型的肺部感染相关的先天免疫的一般话题。专门讨论特定问题的会议 病原体将在上午和晚上举行会议，每个会议由一名经验丰富的讨论负责人领导，通常是一名在以前的会议上介绍过自己的工作的科学家。主题包括细菌性肺炎、肺炎链球菌、金黄色葡萄球菌(尤其是耐甲氧西林金黄色葡萄球菌)、肺炎支原体和百日咳的主要病因。将举行以病毒致病机制和预防为重点的会议，重点是流感、呼吸道合胞病毒和细菌/病毒混合感染。几个讲座将讨论宿主对感染的反应；脂氧素和分解素的参与，上皮信号在宿主防御中的作用，以及中性粒细胞在肺中的招募。下午的海报会议将提供一个非正式的场所来讨论正在进行的工作，并使研究生和博士后能够与他们感兴趣的领域的各种知名人士以及他们的同行见面。在邀请发言者和招募与会者的所有阶段，我们尽一切努力鼓励妇女、代表人数不足的少数群体和残疾人参加。由于肺部感染是美国和全世界死亡的主要原因，这次会议与公共卫生高度相关，并可能促进疾病预防和疫苗开发的新方法。 公共卫生相关性： 急性肺部感染是发病率和死亡率的主要原因，在美国，每年的死亡人数超过艾滋病毒/艾滋病和癌症的总和。尽管有肺炎球菌和流感疫苗可用，但仅在欧洲，2007年社区获得性肺炎的相关医疗费用就超过了20亿美元/年。在美国，2岁以下儿童的RSV住院费用每年超过3.84亿美元。虽然许多不同类型的病原体感染肺部，但对这些感染有保守的粘膜免疫反应。本次会议的目的是为研究急性肺部感染的研究人员提供一个论坛，以更好地了解微生物的发病机制和引起许多病理变化的免疫反应的错综复杂。戈登研究会议将提供一个机会，分享新的假设，讨论新的方法，并建立合作，以更好地了解肺部感染的发病机制，并有望开发更好的预防和治疗策略。

DESCRIPTION: This application requests funding to partially support the third meeting of the Gordon Research Conference on the Biology of Acute Respiratory Infection. This meeting will be held in Ventura, CA March 11-16, 2012 and we expect 110 - 150 scientists to participate. The overarching goal of this multi-disciplinary conference is to provide a setting to present and discuss outstanding research in the area of acute lung infection. As the diverse pathogens that infect the lung activate a limited number of conserved immunologic responses, there is a great deal of information that can be shared by colleagues working in and by colleagues who study different pathogens. General principles of vaccine development, particularly the activation of local immune protection are highly relevant to many different types of pulmonary infection. The meeting will run for 4 1/2 days leading off with presentations each morning dealing with general topics in innate immunity relevant to diverse types of lung infection. Sessions devoted to specific pathogens will be held in morning and evening sessions, each led by an experienced discussion leader, often a scientist who has presented their own work at previous meetings. Topics will include major causes of bacterial pneumonia, Streptococcus pneumoniae, Staphylococcus aureus (especially MRSA) Mycoplasma pneumoniae and pertussis. Sessions focusing upon viral pathogenesis and prevention will be held focusing on influenza, RSV and mixed bacterial/viral infection. Several talks will address the host response to infection; the participation of lipoxins and resolvins, the role of epithelial signaling in host defense, and the recruitment of PMNs to the lung will be included. Afternoon poster sessions will provide an informal venue to discuss work-in progress and enable graduate students and post-docs to meet with various luminaries in their field of interest as well as their peers. At all stages of speaker invitation and recruitment of attendees we have made every effort to encourage participation by women, underrepresented minorities and people with disabilities. As pulmonary infection is a leading cause of mortality in the USA and worldwide this conference is highly relevant to public health and will potentially foster novel approaches to disease prevention and vaccine development. PUBLIC HEALTH RELEVANCE: Acute lung infections are a major cause of morbidity and mortality, associated with a greater number of deaths each year in the USA than HIV/AIDS and cancer combined. The health care associated costs of community-acquired pneumonia in 2007 exceeded 2 billion dollars/year in Europe alone, despite the availability of pneumococcal and influenza vaccines. The cost of RSV hospitalizations for children under 2 years of age in the US exceeds 384 million dollars per year. Although many different types of pathogens infect the lung, there are conserved mucosal immune responses to these infections. The purpose of this conference is to provide a forum for investigators who study acute lung infections to better understand microbial pathogenesis and the intricacies of the immune responses evoked which cause much pathology. This Gordon research Conference will provide an opportunity to share new hypotheses, discuss novel approaches and establish collaborations to better understand the pathogenesis of lung infection and hopefully develop better strategies for prevention and treatment.