2012 Biology of Acute Respiratory Infection Gordon Research Conference

产品说明： 该申请要求资助部分支持急性呼吸道感染生物学戈登研究会议第三次会议。本次会议将于2012年3月11日至16日在加利福尼亚州文图拉举行，预计将有110 - 150名科学家参加。这次多学科会议的总体目标是提供一个环境，介绍和讨论在急性肺部感染领域的杰出研究。由于感染肺部的各种病原体激活有限数量的保守免疫反应，因此研究不同病原体的同事可以分享大量信息。疫苗开发的一般原则，特别是局部免疫保护的激活与许多不同类型的肺部感染高度相关。会议将持续4天半，每天上午进行演讲，讨论与不同类型肺部感染相关的先天免疫的一般主题。专门讨论具体 病原体问题将分上午和晚上两次讨论，每次讨论都由一名经验丰富的讨论负责人主持，通常是在以前会议上介绍过自己工作的科学家。主题将包括细菌性肺炎，肺炎链球菌，金黄色葡萄球菌（特别是MRSA），肺炎支原体和百日咳的主要原因。会议将侧重于病毒的发病机制和预防，重点是流感，RSV和混合细菌/病毒感染。几个会谈将解决主机对感染的反应;参与脂氧素和resolvins，上皮细胞信号传导在主机防御的作用，并招聘中性粒细胞到肺将被包括在内。下午的海报会议将提供一个非正式的场所来讨论正在进行的工作，并使研究生和博士后能够与他们感兴趣的领域的各种名人以及他们的同行见面。在邀请演讲者和招募与会者的所有阶段，我们都尽一切努力鼓励妇女、代表人数不足的少数民族和残疾人参与。由于肺部感染是美国和世界范围内死亡的主要原因，本次会议与公共卫生高度相关，并可能促进疾病预防和疫苗开发的新方法。 公共卫生相关性： 急性肺部感染是发病率和死亡率的主要原因，在美国每年死亡人数超过HIV/AIDS和癌症的总和。2007年，尽管有肺炎球菌和流感疫苗，但仅在欧洲，社区获得性肺炎的医疗保健相关费用就超过了20亿美元/年。在美国，2岁以下儿童的RSV住院费用每年超过3.84亿美元。尽管许多不同类型的病原体感染肺，但对这些感染存在保守的粘膜免疫应答。本次会议的目的是为研究急性肺部感染的研究人员提供一个论坛，以更好地了解微生物的发病机制和引起许多病理的免疫反应的复杂性。这次戈登研究会议将提供一个机会，分享新的假设，讨论新的方法，建立合作，以更好地了解肺部感染的发病机制，并希望制定更好的预防和治疗策略。

DESCRIPTION: This application requests funding to partially support the third meeting of the Gordon Research Conference on the Biology of Acute Respiratory Infection. This meeting will be held in Ventura, CA March 11-16, 2012 and we expect 110 - 150 scientists to participate. The overarching goal of this multi-disciplinary conference is to provide a setting to present and discuss outstanding research in the area of acute lung infection. As the diverse pathogens that infect the lung activate a limited number of conserved immunologic responses, there is a great deal of information that can be shared by colleagues working in and by colleagues who study different pathogens. General principles of vaccine development, particularly the activation of local immune protection are highly relevant to many different types of pulmonary infection. The meeting will run for 4 1/2 days leading off with presentations each morning dealing with general topics in innate immunity relevant to diverse types of lung infection. Sessions devoted to specific pathogens will be held in morning and evening sessions, each led by an experienced discussion leader, often a scientist who has presented their own work at previous meetings. Topics will include major causes of bacterial pneumonia, Streptococcus pneumoniae, Staphylococcus aureus (especially MRSA) Mycoplasma pneumoniae and pertussis. Sessions focusing upon viral pathogenesis and prevention will be held focusing on influenza, RSV and mixed bacterial/viral infection. Several talks will address the host response to infection; the participation of lipoxins and resolvins, the role of epithelial signaling in host defense, and the recruitment of PMNs to the lung will be included. Afternoon poster sessions will provide an informal venue to discuss work-in progress and enable graduate students and post-docs to meet with various luminaries in their field of interest as well as their peers. At all stages of speaker invitation and recruitment of attendees we have made every effort to encourage participation by women, underrepresented minorities and people with disabilities. As pulmonary infection is a leading cause of mortality in the USA and worldwide this conference is highly relevant to public health and will potentially foster novel approaches to disease prevention and vaccine development. PUBLIC HEALTH RELEVANCE: Acute lung infections are a major cause of morbidity and mortality, associated with a greater number of deaths each year in the USA than HIV/AIDS and cancer combined. The health care associated costs of community-acquired pneumonia in 2007 exceeded 2 billion dollars/year in Europe alone, despite the availability of pneumococcal and influenza vaccines. The cost of RSV hospitalizations for children under 2 years of age in the US exceeds 384 million dollars per year. Although many different types of pathogens infect the lung, there are conserved mucosal immune responses to these infections. The purpose of this conference is to provide a forum for investigators who study acute lung infections to better understand microbial pathogenesis and the intricacies of the immune responses evoked which cause much pathology. This Gordon research Conference will provide an opportunity to share new hypotheses, discuss novel approaches and establish collaborations to better understand the pathogenesis of lung infection and hopefully develop better strategies for prevention and treatment.