The Biology and Chemistry of Traditionally Used Anti-Diabetic Botanical Drugs

传统抗糖尿病植物药物的生物学和化学

• 批准号: 8457356
• 负责人: Jordan James Gunn
• 金额: $ 4.22万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8457356
• 关键词: Adipocytes; Alisma; Alismataceae; Antidiabetic Drugs; Area; Benchmarking; Biological; Biological Assay; Biology; Botanicals; Cause of Death; Chemicals; Chemistry; Chinese People; Chinese Traditional Medicine; Complex Mixtures; Cornaceae; Cornus; Data; Detection; Development; Diabetes Mellitus; Disease; Ensure; Fractionation; Generations; Glycogen; Goals; Health; High Pressure Liquid Chromatography; Hong Kong; Insulin; Lead; Materia Medica; Methods; Microscopic; Modeling; Molecular; Nature; Non-Insulin-Dependent Diabetes Mellitus; Pharmaceutical Preparations; Pharmacologic Substance; Plant Preparations; Plants; Poison; Preparation; Public Health; Recording of previous events; Research; Sampling; Series; Source; Standardization; Testing; Toxic effect; United States; Work; combat; cytotoxicity; cytotoxicity test; diabetic; effective therapy; glucose uptake; improved; in vitro Bioassay; lipid biosynthesis; mimetics; novel; prevent

DESCRIPTION (provided by applicant): Type 2 diabetes is a devastating health problem of the world, especially in the United States. Insulin mimetic agents (IMAs) and insulin sensitizing agents (ISAs) are two types of anti-diabetic agents being used to combat this disease, and they are active areas of research for developing new treatments. This project seeks to isolate and identify novel IMAs and/or ISAs from Cornus officinalis and Alisma orientale, two plant species used in traditional Chinese medicine for the treatment of diabetes. Through a series of in vitro bioassays tracking toxicity and insulin dependent glucose uptake in primary and cultured adipocytes, active components will be isolated and identified. The results of this study will serve as baseline data for the standardization of anti-diabetic formulas containing these plants, and provide lead compounds for the pharmaceutical development of anti-diabetic drugs. PUBLIC HEALTH RELEVANCE: This project seeks to isolate anti-diabetic compounds from two plant species used in traditional Chinese medicine. The proposed work is relevant to public health because Type-2-diabetes is the seventh leading cause of death in the United States, and all indications suggest that this number will not improve without the development of new and better drugs. Plants, especially those with a history of use to treat diabetes, are an excellent source for the discovery of lead compounds, which may be developed into a new generation of pharmaceuticals. Furthermore, the standardization by active ingredients of herbal preparations in use to treat diabetes is expected to lead to safe and effective treatment options.

描述(申请人提供)：2型糖尿病是一个毁灭性的世界健康问题，特别是在美国。胰岛素模拟剂(IMA)和胰岛素增敏剂(ISA)是目前用于治疗糖尿病的两类抗糖尿病药物，它们是开发新疗法的活跃研究领域。本项目旨在从山茱萸和泽泻中分离和鉴定新的IMA和/或ISA，这两种植物在传统中药中用于治疗糖尿病。通过一系列跟踪原代和培养的脂肪细胞的毒性和胰岛素依赖的葡萄糖摄取的体外生物测定，活性成分将被分离和鉴定。这项研究的结果将有助于 作为含有这些植物的降糖配方标准化的基线数据，并为降糖药物的药物开发提供先导化合物。 公共卫生相关性：该项目旨在从两种中药中使用的植物中分离出抗糖尿病化合物。这项拟议的工作与公共健康相关，因为2型糖尿病是美国第七大死亡原因，所有迹象都表明，如果不开发新的更好的药物，这一数字不会有所改善。植物，特别是那些有治疗糖尿病历史的植物，是发现先导化合物的极好来源，这种化合物可能会被开发成新一代药物。此外，通过对用于治疗糖尿病的草药制剂的活性成分进行标准化，有望产生安全有效的治疗方案。