Preparation for GTP long-term clinical study on bone health

骨质疏松症是绝经后妇女的主要健康问题。我们的长期目标是 制定补充和替代医学（CAM）干预措施，包括 膳食补充剂（绿色茶多酚，GTP）对骨骼健康。总体目标 U 01申请的目的是找到GTP的最佳剂量， 绝经后骨质减少妇女长期补充GTP的临床试验。我们 中心假设是GTP将通过增加骨密度来改善骨骼健康。 形成和减少骨吸收。有4个不同的项目涉及到 拟定研究：项目1 -血清样本中的骨生物标志物测量;项目 2 -临床前动物剂量反应GTP研究;项目3 -证明BMD 项目4 -GTP的人体剂量反应研究。的 这项研究的意义在于其CAM方法可以减轻骨丢失， 绝经后妇女。

Osteoporosis is a major health issue in postmenopausal women. Our long-term goal is to develop a complementary and alternative medicine (CAM) intervention including dietary supplement (green tea polyphenols, GTP) for bone health. The overall objective of this U01 application is to find an optimal dose of GTP that would be employed to a long-term GTP supplementation clinical trial in postmenopausal osteopenic women. Our central hypothesis is that the GTP will improve bone health through increasing bone formation and decreasing bone resorption. There are 4 different projects involved in the proposed study: Project 1 - bone biomarker measurement in the serum samples; Project 2 -preclinical animal dose-response GTP study; Project 3 - demonstrate BMD measurement proficiency; and Project 4 - human dose-response study of GTP. The significance of this study is in its CAM approach to the mitigation of bone loss in postmenopausal women.