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Neuromuscular neutral zones in humans: A new method to assess spinal stability

人类神经肌肉中性区：评估脊柱稳定性的新方法

基本信息

批准号：
8305413
负责人：
Bradley Davidson
金额：
$ 18.52万
依托单位：
UNIVERSITY OF DENVER (COLORADO SEMINARY)
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8305413
关键词：
Agreement Award Belief Biomechanics Clinical Clinical Trials Design Colorado Diagnosis Diagnostic Doctor of Chiropractic Ensure Family Felidae Female Future Goals Human Individual Instruction Investigation Joint Laxity Kinesiology Laboratories Lateral Lesion Ligaments Low Back Pain Manipulative Therapies Measurement Measures Mechanoreceptors Mediating Mentors Methodology Methods Metric Modeling Motion Movement Muscle Nature Pain Participant Patients Phase Physiological Population Positioning Attribute Publications Quadratus Lumborum Muscle Radial Reflex action Relaxation Research Research Technics Rotation Sex Characteristics Spinal Stretching Structure Sum Techniques Testing Therapeutic Time Tissues Universities Variant Vertebral column base early onset effective therapy improved in vivo insight kinematics male neuromuscular patient population sex spine bone structure

项目摘要

The long-term goals of this research are to gain insight into mechanisms of spinal stability and develop measurement techniques that will be critical for assessing the effects of spinal manipulative therapy (SMT) on ligament-mediated reflexes in healthy individuals and patients with low back pain. The basis of this investigation is that neuromuscular mechanisms of spinal stability are inherently connected with the structure of the spine and surrounding tissues. Therefore, techniques of SMT likely have a direct effect on mechanoreceptors in the passive tissue that may alleviate pain during movement by improving timing of stabilizing reflexes in the lumbar spine as defined by neuromuscular neutral zones (NNZs). In order to investigate the effects of manipulative therapy on NNZs, the presence and reliability of measuring these in humans must first be established using a healthy population. The mentored phase (K99) of this award will last one year, and be used to demonstrate the presence of NNZs in humans, examine which muscle are involved, and scrutinize their interactions within this phenomenon. Three hypotheses will be tested that are relevant to this single specific aim. The independent phase (ROO) will last three years, and is centered on two specific aims. The first aim will be to develop a non-invasive technique to measure intervertebral kinematics. The second aim will be to establish reliable methodology to quantify NNZs, examine differences between three rotational paradigms, and investigate sex effects on these measures. Four hypotheses will be tested relevant to these aims. This research will be conducted in a movement science laboratory located at the University of Colorado Denver. Successful completion of this research will provide foundational methodology for future testing in patient populations and implementing clinical trials designed to gain insight into therapeutic mechanisms of SMT and physiological nature of functional spinal lesions. This research trajectory will provide quantitative and evaluative assistance to clinicians when diagnosing and treating the large population of patients who seek therapy for low back pain.

本研究的长期目标是深入了解脊柱稳定性和发育的机制