Administrative Core

核心摘要：行政共享研究资源(核心A)将支持赠款和 三个研究项目、发展(试点)项目、跨BETRNet项目和其他跨BETRNet活动的监管管理需求。授权管理职责包括准备和执行研究中心预算，向参与机构分配分包合同，执行财务会计，以及与NCI项目经理沟通。此外，该中心还将编写研究中心的进度报告，定期安排电话会议，并为BETRNet工作组提供支持。此外，该核心将履行监管管理职责，包括为临床研究准备人体受试者方案和为验证研究准备组织采购方案。该核心将与机构IRB进行沟通，并为第一阶段研究准备同意书、病例报告表和患者招募表格。此外，该中心将安排对多肽进行药理学和毒理学研究，与MICHR合作准备向美国食品和药物管理局(FDA)提交新药申请调查。该中心由主任王天明博士领导，并得到研究中心拨款管理人Michele Bushaw Weston女士的支持。

Core Summary: The Administration Shared Research Resource (Core A) will support the grants and regulatory management needs for the three research projects, developmental (pilot) projects, cross-BETRNet projects, and other cross-BETRNet activities. Grant management responsibilities include preparing and implementing the Research Center budgets, allocating sub-contracts to participating institutions, performing financial accounting, and communicating with the NCI program managers. In addition, this Core will prepare the Research Center progress reports, set up the regularly scheduled teleconferences, and support the BETRNet working groups. Furthermore, this Core will fulfill the regulatory management responsibilities, including preparing the human subjects protocols for the clinical studies and tissue procurement protocols for the validation studies. This Core will communicate with the institutional IRB and prepare consent forms, case report forms, and patient recruitment tables for the Phase 1 studies. In addition, this Core will arrange for the pharmacology & toxicology studies on the peptides to be performed, work with MICHR to prepare the Investigation of New Drug applications to the US Food and Drug Administration (FDA). This Core is led by the Director Dr. TD Wang with support from the Research Center grants administrator Ms. Michele Bushaw Weston.