Advancing Reproductive Health: Qualitative Methods & Interdisciplinary Mentorship

描述（由申请人提供）：这个职业中期研究者奖（K24）将提供受保护的时间，资源和结构，这将允许我在研究生涯轨迹上取得进展，从主要关注艾滋病毒预防，到在更广泛的性和生殖健康（SRH）背景下更包容和广泛的预防概念。此外，它将使我能够在以患者为导向的研究中使用混合方法的综合过程中进行指导。我的职业发展目标是：1)将我的知识和专业知识从单纯的艾滋病毒预防扩展到对性健康和生殖健康的更广泛的关注，2)将扩展的研究议程推进到有效的性健康和生殖健康技术和干预措施的发展，以及3)通过指导研究员和初级研究人员在以患者为导向的研究中提高我在使用混合方法研究健康促进科学方面的学术地位。拟议的指导计划将使我能够投入必要的时间和精力，将综合的混合方法研究培训计划充分融入我对初级研究人员的指导中。拟议的研究将为指导这些调查人员提供背景。结构化的指导计划将使我能够为对预防干预和治疗评估研究感兴趣的初级研究人员提供科学领导和深入的方法培训。通过对最先进的科学混合方法的指导，我将推动在广泛的健康促进科学领域进行严格的健康促进研究。我的职业中期发展计划将允许我从事学习和研究活动，将我的知识基础和专业知识扩展到SRH，并帮助我更好地了解SRH技术的用户体验，并确定影响使用的因素。使用的关键是“可接受性”。然而，目前关于坚持和可接受性的概念未能充分阐明和说明使用和不使用的模式。我建议需要一个新的使用模型，“有效使用”，并建议进行纵向前瞻性混合方法研究来阐明这个模型。“有效使用”的概念源于对最佳用户体验的内在需求。它认为，用户的积极体验驱动了使用，并且由于使用是由这种积极体验维持的，因此无论是用于预防还是治疗，都可以获得更高的生物医学干预（例如，活性成分）。与公共卫生的相关性：性健康和生殖健康是全球公共卫生的优先事项。提供最有可能使用的有效性健康和生殖健康技术将对妇女的健康产生最大的影响。如果取得成功，有效利用模式将为妇女及其伴侣开发性健康和生殖健康技术提供一个新的范例，从而增加使用并改善性健康和生殖健康成果。

DESCRIPTION (provided by applicant): This midcareer investigator award (K24) will provide protected time, resources, and structure that will allow for a progression in my research career trajectory, from a primary focus on HIV prevention, to a more inclusive and extensive conceptualization of prevention in the broader context of sexual and reproductive health (SRH). Further, it will allow me to engage in a comprehensive process of mentorship in the use of mixed methodologies in patient-oriented research. My career development goals are to: 1) expand my knowledge and expertise from HIV prevention alone to a more inclusive focus on sexual and reproductive health, 2) advance an expanded research agenda into the development of effective sexual and reproductive health technologies and interventions, and 3) advance my scholarly role in the use of mixed methods research for health promotion sciences by mentoring fellows and junior investigators in patient oriented research. The proposed mentorship plan will allow me to dedicate the necessary time and effort to fully integrate a comprehensive mixed methods research training program into my mentoring of junior investigators. The proposed research will provide the context for mentoring those investigators. The structured mentorship program will allow me to provide scientific leadership and in-depth methodological training for junior investigators interested in prevention intervention and treatment evaluation research. Through this mentorship in state-of-the-science mixed methods, I will promote the conduct of rigorous health promotion research across a wide range of health promotion sciences. My midcareer development plan will allow me to pursue learning and research activities that broaden my knowledge base and expertise into SRH and help me to better understand user experiences with SRH technologies, and identify those factors that impact use. Critical to use is "acceptability." However, current conceptualizations of adherence and acceptability fail to fully articulate and account for patterns of use and non-use. I propose that a new model of use, "Effective Use," is required, and propose the conduct of a longitudinal prospective mixed methods study to articulate this model. The concept of "Effective Use" begins with an inherent demand for the best user experience. It holds that a user's positive experience drives use, and that because use is maintained by this positive experience, higher exposure to the biomedical intervention (e.g., active ingredient), whether for prevention or treatment, is achieved. Relevance to Public Health: Sexual and reproductive health is a global public health priority. Providing efficacious SRH technologies that have the greatest likelihood of use will have the greatest impact on women's health. If successful, an Effective Use model would offer a new paradigm for the development of sexual and reproductive health technologies for women and their partners that will result in increased use and improved sexual and reproductive health outcomes. PUBLIC HEALTH RELEVANCE: This K24 award will provide me with protected time to conduct mixed methods research that will articulate a new paradigm for the development of sexual and reproductive health technologies: specific to my research, our ability to develop technologies that have the greatest likelihood of use will have the greatest impact on women's sexual and reproductive health, a global public health priority. The K24 award will also allow time to implement a comprehensive mixed methods mentorship program to train a new cadre of researchers in the health promotion sciences