基于水凝胶颗粒的 microRNA 分析用于发现和癌症诊断-猫眼课题宝

基于水凝胶颗粒的 microRNA 分析用于发现和癌症诊断

批准号：

8304197

负责人：

Patrick S Doyle

金额：

$66.44万

依托单位：

FIREFLY BIOWORKS, INC.

依托单位国家：

美国

项目类别：

财政年份：

2009

资助国家：

美国

项目状态：

已结题

起止时间：

2009-09-01 至 2014-03-31

来源：

https://reporter.nih.gov/project-details/8304197

关键词：

Acute Myelocytic Leukemia Alzheimer&apos s Disease Biological Assay Cancer Diagnostics Cells Clinical Collaborations Comparative Study Complementary DNA Custom Cytolysis Detection Devices Diabetes Mellitus Diagnosis Discrimination Disease Ensure Fireflies Functional RNA Gel Genes Goals Heart Diseases Hour Human Hydrogels Label Laboratories Liquid substance Literature Malignant Neoplasms MicroRNAs Molecular Profiling National Cancer Institute Nucleic Acids Nucleotides Optics Patients Performance Phase RNA RNA purification Research Sampling Scanning Scheme Sequence Homology Serum Specificity Structure System Technology Validation Variant Work anticancer research base cancer type commercialization density design drug discovery experience high throughput screening lithography meetings particle phase 1 study phase 2 study professor prototype scale up success tool

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英文摘要

DESCRIPTION (provided by applicant): MicroRNA targets have shown enormous potential for understanding, diagnosing, and even treating the world's most prevalent diseases including cancer, heart disease, Alzheimer's, diabetes and many more. Unfortunately, miRNAs are particularly challenging to quantify due to their small size, sequence homology, and wide range of abundance. As such, miRNA profiling is either expensive or low-throughput using today's state-of-the art technologies. To overcome these limitations, a new multiplexing technology built on encoded hydrogel microparticles and a custom microRNA labeling scheme will be scaled up, automated, and validated. This project could have implications in cancer research, drug discovery, and cancer diagnostics.

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