Cancer Center Support Grant

描述（由申请人提供）：对癌症的遗传理解已经提高了个体风险评估，改进了筛查指南，改善了基于癌症预防、早期发现和在某些情况下靶向治疗的结果。亨斯迈癌症研究所（HCI）定位于在这个个体化肿瘤领域做出卓越的贡献。HCI拥有独特的研究资源来支持遗传和人口研究，犹他州人口数据库（UPDB），肿瘤学遗传发现的引人注目的历史，以及加速该平台转化进展的战略计划。我们已经与全国知名的犹他州健康网络Intermountain Healthcare建立了联盟，将我们州超过80- 85%的癌症患者的数据与UPDB联系起来，使整个犹他州的人口能够组成一个癌症研究实验室，进行基因、人口和结果研究。犹他州是七个美洲原住民部落或民族的家园，还有大量的农村和边境人口，他们的癌症预后很差。我们的目标是作为一个国家研究资源，解决这些服务不足的人群的需求，以改善癌症预防和护理。

DESCRIPTION (provided by applicant): The genetic understanding of cancer has led to enhanced individual risk assessment, improved screening guidelines, and improved outcomes based on cancer prevention, early detection, and, in some cases, targeted therapy. Huntsman Cancer Institute (HCI) is positioned to make exceptional contributions in this individualized oncology arena. HCI has a unique research resource to support genetic and population studies, the Utah Population Database (UPDB), a compelling history of genetic discovery in oncology, and a strategic plan to accelerate translational advances from this platform. We have forged an alliance with Intermountain Healthcare, a nationally acclaimed Utah health network, linking data for more than 80-85 percent of the cancer patients in our State to the UPDB, enabling the entire population of Utah to comprise a cancer research laboratory for genetic, population, and outcomes research. Utah is home to seven Native American tribes or nations as well as extensive rural and frontier populations that have poor cancer outcomes. We aim to serve as a national research resource for addressing the needs of these underserved populations to improve cancer prevention and care. HCI research is organized into five Programs that provide an environment of cancer focus, transdisciplinary exchange, and collaboration: Nuclear Control of Cell Growth and Differentiation; Cell Response and Regulation; Imaging, Diagnostics, and Therapeutics; Gastrointestinal Cancers; and Cancer Control and Population Sciences. These Programs integrate the activities of 133 members who have $45 million in extramural grant support, with more than $17 million in NCI direct costs. Cancer-focused research during the current award period is documented in 1,374 unique publications, of which 26 percent are collaborative with one or more Cancer Center members. Thirteen Cancer Center Shared Resources support our scientists, providing access to specialized instrumentation, assays, services, research materials, and expert consultation and collaboration. We request funds to support Years 21-25 of our Cancer Center Support Grant (CCSG). A new Executive Director, Mary Beckerle, Ph.D., was appointed in August 2006. Under her leadership, HCI has developed a plan to guide the next five years, including expansion of HCI's cancer specialty hospital, expansion of HCI's genetic platform for pre-clinical studies, development of a Center for Investigational Therapeutics (including a Phase I program), and expansion of population science (including epidemiological and behavioral research) to impact care of cancer survivors and reduce health disparities.