1/4 Alcohol Research Consortium in HIV-Administrative Core (ARCH-AC)

描述（由申请人提供）：艾滋病毒酒精研究联盟（ARCH）由两个U24和两个UOI申请组成，将解决有关艾滋病毒感染中危险酒精使用/滥用/依赖的临床流行病学的关键问题（流行病学研究部门），并评估在现实世界艾滋病毒诊所环境中基于证据的酒精减少策略的相对有效性（干预研究部门）。这项研究建立在一个完善的HIV临床队列的独特优势之上，CFAR综合临床系统网络（CNICS）由美国8个诊所和超过20,000名HIV感染者组成。这个动态队列通过收集全面的临床数据和标本，以及作为患者报告结果测量信息系统倡议的一部分统一收集患者报告的结果，为HIV和酒精的长期研究提供了理想的科学平台。流行病学/生物统计学核心将由流行病学和生物统计学专家领导，特别侧重于艾滋病毒研究。它将为U01应用程序的科学议程提供关键支持，并专注于创新分析策略的开发，以最大限度地提高新的临床和科学知识。ARCH的核心U24是管理核心（Administrative Core， AC），它是这个应用程序的重点。ARCH-AC将提供关键的基础设施来协调和促进该联盟的科学目标。结构将包括：一个执行委员会；指导委员会；制定和实施研究目标的关键科学工作组；还有一个社区顾问委员会。酒精使用障碍研究中心由酒精使用障碍和艾滋病毒方面的国家专家共同领导，他们在开展艾滋病毒/艾滋病流行病学和临床研究方面拥有40多年的综合科学经验。咨询委员会提供关键的基础设施，以便：1)构思、促进和监督科学流行病学和干预目标的实施；2)促进ARCH各组成部分与调查人员之间的沟通与协作；3)管理和优化ARCH资源的获取，特别是数据库、流行病学/生物统计学支持和调查专业知识；4)为ARCH研究结果的传播提供支持。

DESCRIPTION (provided by applicant): Alcohol Research Consortium in HIV (ARCH) is comprised of two U24 and two UOI applications, and will address critical questions regarding the clinical epidemiology of hazardous alcohol use/abuse/dependence in HIV infection (Epidemiology Research Arm), and evaluate the comparative effectiveness of evidence- based alcohol reduction strategies in real world HIV clinic settings (Intervention Research Arm). This research builds upon the unique strengths of a well-established HIV clinical cohort, the CFAR Network of Integrated Clinical Systems (CNICS), comprised of 8 clinics and over 20,000 HIV-infected individuals across the United States. This dynamic cohort provides an ideal scientific platform for long-term study of HIV and alcohol through the collection of comprehensive clinical data and specimens as well as uniformly-collected patient reported outcomes as a part of the Patient Reported Outcomes Measurement Information System initiative. An Epidemlology/Biostatistics Core will be led by experts in epidemiology and biostatistics with specific focus on HIV research. It will provide critical support for the scientific agenda of the U01 applications and focus on development of innovative analytic strategies that will maximize new clinical and scientific knowledge. The U24 at the heart of ARCH is the Administrative Core (AC), the focus of this application. ARCH-AC will provide the critical infrastructure to coordinate and facilitate the consortium's scientific goals. Structure will include: an executive committee; a steering committee; key scientific working groups to conceptualize and implement study aims; and a community advisory board. ARCH-AC is co-led by national experts in alcohol use disorders and HIV, who have over 40 years of combined scientific experience in conducting epidemiologic and clinical research in HIV/AIDS. The AC provides the critical infrastructure to: 1) conceptualize, facilitate and oversee the implementation of the scientific epidemiologic and interventional aims; 2) promote communication and collaboration among ARCH components and investigators; 3) manage and optimize access to ARCH resources, particularly the data repositories, epidemiologic/ biostatistics support and the investigational expertise; and 4) provide the support for dissemination of ARCH findings.