OTHER FUNCTIONS DEVELOPMENT OF TOOLS FOR CRYOGENIC BIOPSY OF SOFT TISSUE.
OTHER FUNCTIONS DEVELOPMENT OF TOOLS FOR CRYOGENIC BIOPSY OF SOFT TISSUE.
批准号:
8565083
负责人:
EREZ NEVO
金额:
$199.99万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-09-28 至 2014-09-27
关键词:
AblationAdvanced Malignant NeoplasmAnimalsBiological AssayBiological MarkersBiological PreservationBiopsyBiopsy SpecimenCellsCharacteristicsClinicClinicalClinical ResearchContractsDataDevicesHumanImageInstructionIschemiaLasersLettersMarketingMeasuresMolecularMolecular MedicineMonitorMorphologyOncologistOperative Surgical ProceduresPathologistPatientsPatternPerformanceProceduresProcessPublicationsQuality ControlRadiofrequency Interstitial AblationSamplingSpecific qualifier valueSpecimenSurgeonSystemTestingTherapeuticTissue SampleTissuesWritingXenograft Modelcancer diagnosiscancer therapycryogenicsdesignimprovedinstrumentinterestmicrowave electromagnetic radiationoperationpilot trialpreventradiologistsoft tissuetool developmenttumor
中文摘要
如果生物标记物可以,分子医学有望推进癌症的诊断和治疗
英文摘要
Molecular medicine holds promise for advancing cancer diagnosis and treatment if biomarkers can be
accurately assessed in tumors. The objective of the project is to develop and test a new biopsy system that
stabilizes the target tissue and prevents changes in biomarker levels due to ischemia in the excised tissue
sample. The specific aims of the project are:
1. Design and build a clinic-ready, stand-alone cryobiopsy device
2. Develop and validate an assay for assessing molecular biomarker preservation
3. Design and conduct studies of the device in xenograft model
4. Conduct a pilot clinical study of the device in selected human tumors
5. Initiate the process to achieve FDA clearance of the device
A biopsy device that preserves the tissue morphology and stabilizes the biomolecular profile of the cells in
the sample is expected to find a wide market and many clinical and research applications. In particular, such
a device can be used to monitor the effect of specifically-targeted treatment and to improve the management
of patients by the use of individualized therapy that targets the specific characteristics of the tumor in each
patient.
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TOPIC 383: MULTI-CORE BIOPSY DEVICE WITH VOLUMETRIC FIELD OF TISSUE ACQUISITION (MOONSHOT)
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批准号:10032972
-
项目类别:
-
资助金额:$30.0万
-
财政年份:2019
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负责人:EREZ NEVO
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依托单位:
TOPIC 383: MULTI-CORE BIOPSY DEVICE WITH VOLUMETRIC FIELD OF TISSUE ACQUISITION (MOONSHOT)
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批准号:10250297
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项目类别:
-
资助金额:$200.0万
-
财政年份:2019
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负责人:EREZ NEVO
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依托单位:
TAS::75 0849::TAS
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批准号:8164216
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项目类别:
-
资助金额:$25.0万
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财政年份:2010
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负责人:EREZ NEVO
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依托单位: