OTHER FUNCTIONS DEVELOPMENT OF TOOLS FOR CRYOGENIC BIOPSY OF SOFT TISSUE.

其他功能 软组织低温活检工具的开发。

• 批准号: 8565083
• 负责人: EREZ NEVO
• 金额: $ 199.99万
• 依托单位: ROBIN MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-28 至 2014-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8565083
• 关键词: Ablation; Advanced Malignant Neoplasm; Animals; Biological Assay; Biological Markers; Biological Preservation; Biopsy; Biopsy Specimen; Cells; Characteristics; Clinic; Clinical; Clinical Research; Contracts; Data; Devices; Human; Image; Instruction; Ischemia; Lasers; Letters; Marketing; Measures; Molecular; Molecular Medicine; Monitor; Morphology; Oncologist; Operative Surgical Procedures; Pathologist; Patients; Pattern; Performance; Procedures; Process; Publications; Quality Control; Radiofrequency Interstitial Ablation; Sampling; Specific qualifier value; Specimen; Surgeon; System; Testing; Therapeutic; Tissue Sample; Tissues; Writing; Xenograft Model; cancer diagnosis; cancer therapy; cryogenics; design; improved; instrument; interest; microwave electromagnetic radiation; operation; pilot trial; prevent; radiologist; soft tissue; tool development; tumor

Molecular medicine holds promise for advancing cancer diagnosis and treatment if biomarkers can be accurately assessed in tumors. The objective of the project is to develop and test a new biopsy system that stabilizes the target tissue and prevents changes in biomarker levels due to ischemia in the excised tissue sample. The specific aims of the project are: 1. Design and build a clinic-ready, stand-alone cryobiopsy device 2. Develop and validate an assay for assessing molecular biomarker preservation 3. Design and conduct studies of the device in xenograft model 4. Conduct a pilot clinical study of the device in selected human tumors 5. Initiate the process to achieve FDA clearance of the device A biopsy device that preserves the tissue morphology and stabilizes the biomolecular profile of the cells in the sample is expected to find a wide market and many clinical and research applications. In particular, such a device can be used to monitor the effect of specifically-targeted treatment and to improve the management of patients by the use of individualized therapy that targets the specific characteristics of the tumor in each patient.

如果生物标记物可以，分子医学有望推进癌症的诊断和治疗