OTHER FUNCTIONS DEVELOPMENT OF TOOLS FOR CRYOGENIC BIOPSY OF SOFT TISSUE.

分子医学有望推动癌症诊断和治疗，如果生物标记物可以 在肿瘤中被准确评估。该项目的目标是开发和测试一种新的活组织检查系统， 稳定靶组织并防止由于切除组织中的缺血而引起的生物标志物水平的变化 样本。该项目的具体目标是： 1.设计和制造可供临床使用的独立低温立体检验仪 2.建立和验证分子生物标记物保存性评估方法 3.异种移植模型装置的设计与研究 4.在选定的人类肿瘤中进行该设备的试点临床研究 5.启动流程以实现FDA对该设备的批准 一种活组织检查装置，可保存组织形态并稳定细胞的生物分子图谱。 预计该样品将有广阔的市场和许多临床和研究应用。特别是，这样的 可以使用设备来监控特定靶向治疗的效果并改进管理 通过使用针对每个肿瘤的特定特征的个体化治疗 有耐心的。

Molecular medicine holds promise for advancing cancer diagnosis and treatment if biomarkers can be accurately assessed in tumors. The objective of the project is to develop and test a new biopsy system that stabilizes the target tissue and prevents changes in biomarker levels due to ischemia in the excised tissue sample. The specific aims of the project are: 1. Design and build a clinic-ready, stand-alone cryobiopsy device 2. Develop and validate an assay for assessing molecular biomarker preservation 3. Design and conduct studies of the device in xenograft model 4. Conduct a pilot clinical study of the device in selected human tumors 5. Initiate the process to achieve FDA clearance of the device A biopsy device that preserves the tissue morphology and stabilizes the biomolecular profile of the cells in the sample is expected to find a wide market and many clinical and research applications. In particular, such a device can be used to monitor the effect of specifically-targeted treatment and to improve the management of patients by the use of individualized therapy that targets the specific characteristics of the tumor in each patient.