Boston OAIC: A Translational Approach to Function Promoting Anabolic Therapies

波士顿 OAIC：促进合成代谢疗法功能的转化方法

• 批准号: 8301627
• 负责人: SHALENDER BHASIN
• 金额: $ 109.42万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8301627
• 关键词: Aging; American; Basic Science; Biological Markers; Biological Models; Biology; Boston; Caloric Restriction; Centenarian; Clinic; Clinical; Clinical Research; Collaborations; Communities; Community Outreach; Computer Assisted; Core Facility; Dependence; Development; Discipline; Education; Elderly; Endocrinology; Epidemiologic Studies; Epidemiology; Event; Exercise; Exercise Physiology; Fostering; Fracture; Framingham Heart Study; Funding; Generations; Geriatrics; Gerontology; Grooming; Health Services; Human; Individual; Interdisciplinary Study; Intervention Trial; K-Series Research Career Programs; Leadership; Link; Massachusetts; Mentors; Methods; Modality; Molecular Genetics; Monitor; Muscle; New England; Newsletter; Nutritional; Outcome; Outcome Assessment; Outcome Measure; Physical Function; Physical activity; Pilot Projects; Positioning Attribute; Prevention; Process; Quality of life; Recording of previous events; Recruitment Activity; Research; Research Activity; Research Infrastructure; Research Personnel; Research Training; Resources; Scientist; Signal Transduction; Stem cells; Structure; Systems Biology; Technology; Testosterone; Training; Training Programs; Translational Research; Translations; United States National Institutes of Health; Universities; Validation; age related; base; bench to bedside; career development; cohort; cost; disability; drug discovery; efficacy trial; evidence base; experience; fall risk; functional decline; improved; innovation; instrument; interdisciplinary approach; interdisciplinary collaboration; male; meetings; member; method development; mortality; next generation; novel; nutrition; older men; pre-clinical; programs; therapy development; tool; translational approach; web site

DESCRIPTION (provided by applicant): Functional decline and dependence in older individuals portend poor outcome, and impose a large burden on health care services and costs. Therefore, function promoting anabolic therapies (FPATs) that improve physical function and reduce the burden of disabling functional limitations are desirable. The Boston Claude A. Pepper Older Americans Independence Center (OAIC) with its thematic focus on functional limitations and FPATs will integrate 13 NIH-funded studies, 4 innovative pilot projects, and 2 developmental projects into a cohesive interdisciplinary program that is supported by a Leadership and Administrative Core, a Research Career Development Core (RCDC), a Pilot and Exploratory StudieSxCore, and three resource cores (Function Assessment Core, Muscle Progenitor Cell Core, and Systems Biology Core). The Boston OAIC is unique in its positioning across the entire spectrum of translational discovery research: 13 OAIC projects, and pilot and developmental projects will elucidate the epidemiology of functional limitations and mechanisms of FPAT action, help identify targets for FPAT discovery and biomarkers of FPAT action, and facilitate methods development, outcomes validation, and efficacy trials of leading FPATs. The RCDC will recruit the best candidates from several disciplines, induing Geriatrics and Gerontology, and train them through a structured didactic education and mentored research program. Integration across OAIC will be achieved by weekly interdisciplinary research meetings, biannual retreats, a website, common thematic focus, and the PROMOTE program aimed at promoting collaboration. Community outreach and dissemination of OAIC activities will be achieved through Ambassador's Program which will organize community events, a newsletter, and a Community Advisory Board. Unique strengths of OAIC include its focus on FPATs, emphasis on innovation, its extension across entire spectrum of translational research from mechanism elucidation to efficacy trials, a history of productive collaborations among its members, strong infrastructure and institutional commitment, and inclusion of several important epidemiologic investigations (FHS, MMAS, BACH, Centenarian Study, and BOKS), FPAT intervention trials, and mechanism-based FPAT discoveries. Boston OAlC's collaborative strategies should help expedite the translation of research results into evidence-based FPATs and nurture a new generation of aging researchers. PROGRAM AS A WHOLE

描述（由申请人提供）：老年人的功能衰退和依赖预示着不良的结果，并对医疗保健服务和成本造成很大的负担。因此，功能促进合成代谢疗法（FPATs）可以改善身体功能，减轻残疾功能限制的负担。波士顿克劳德·a·佩珀老年美国人独立中心（OAIC）以功能限制和FPATs为主题，将把13项美国国立卫生研究院资助的研究、4个创新试点项目和2个发展项目整合成一个有凝聚力的跨学科项目，该项目由领导和行政核心研究中心提供支持