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UTI in Nursing Home Residents: Research Training and Clinical Investigation

疗养院居民的尿路感染：研究培训和临床调查

基本信息

批准号：
8261331
负责人：
MANISHA JUTHANI-MEHTA
金额：
$ 15.97万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-15 至 2014-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8261331
关键词：
Acute Adverse drug effect Antibiotic Therapy Antibiotic-resistant organism Area Bacteremia Bacteria Bacteriuria Burn injury Caring Cessation of life Chronic Disease Clinical Clinical Trials Clinical Trials Design Colony-forming units Communicable Diseases Consensus Data Development Development Plans Diagnosis Discipline of Nursing Dysuria Elderly Environment Epidemiology Expenditure Fatigue Fever Flank Pain Frequencies Future Geriatrics Goals Gold Growth Healthcare Hematuria Increased frequency of micturition Indwelling Catheter Infection Infection Control Infectious Disease Epidemiology Inflammatory Response Interview Investigation Laboratories Lead Leukocytes Licensed Practical Nurse Long-Term Care Longitudinal Studies Malaise Medical Mentors Mentorship Methodology Nurses Nursing Homes Nursing Staff Odors Outcome Pain Pattern Personal Satisfaction Physicians Psyche structure Public Health Pyuria Registered nurse Research Research Design Research Personnel Research Training Risk Sepsis Specimen Symptoms Temperature Time Training Universities Urinalysis Urinary tract Urinary tract infection Urination Urine Validation Vulnerable Populations adverse outcome base career development clinical epidemiology cohort evidence base functional decline functional status health care delivery improved meetings member mental state micturition urgency milliliter mortality pathogen patient oriented programs skills urinary

项目摘要

DESCRIPTION (provided by applicant): Improving health care delivery for older adults requires investigation by both trained geriatricians and subspecialists with a geriatric focus. Infections in older adults are a common public health problem that lead to functional decline, mortality, and healthcare expenditures. Nursing home residents, in particular, are a vulnerable population in whom further investigation is warranted to optimize medical care. Urinary tract infection (DTI) in nursing home residents is an investigatively understudied topic. The primary goal of this application is to train Dr. Juthani-Mehta, the candidate, to be an investigative leader in geriatric infectious diseases and to advance multidisciplanary research in UTI in nursing home residents. The short-term goals of the career development plan are: 1) to establish the candidate as a patientoriented investigator at the interface of infectious diseases, geriatric medicine, and nursing home practice; 2) to gain additional training and mentorship in chronic disease epidemiology, infectious diseases epidemiology, and longitudinal study design; and 3) to obtain skills in clinical trial design, geriatric medicine, and infection control methodology in nursing homes that will be necessary for future studies. The long-term goal is to train the candidate to be an investigative leader in the field of infections in older adults prepared to conduct multi-center observational and interventional clinical trials in long-term care facilities. The specific aims of the research plan are: 1) to determine the reliability of UTI specific (e.g. flank pain or tenderness) and UTI non-specific (e.g., change in mental status) clinical features as assessed by nursing staff in nursing home residents with suspected UTI; 2) to identify those reliable clinical features in residents with suspected UTI that are associated with laboratory evidence of UTI (i.e., bacteriuria plus pyuria) to create an evidencebased definition of UTI; and 3) to validate the combination of clinical features that are both reliable and associated with laboratory evidence of UTI in a separate validation cohort of nursing home residents with suspected UTI. The candidate is an emerging patient-oriented investigator with unique training in infectious diseases and geriatric clinical epidemiology that make her an ideal candidate to be among the investigative leaders in this field. The renowned mentors she has assembled and the environment at Yale University will allow for outstanding training and the successful completion of the proposed study.

描述（由申请人提供）：改善老年人的医疗保健服务需要经过培训的老年病学家和以老年病为重点的专科医生进行调查。老年人感染是一个常见的公共卫生问题，导致功能下降，死亡率和医疗保健支出。养老院居民，特别是，是一个脆弱的人群，其中有必要进一步调查，以优化医疗服务。护理之家居民的尿路感染（DTI）是一个调查研究不足的话题。该申请的主要目标是培养候选人Juthani-Mehta博士成为老年传染病的调查领导者，并在养老院居民中推进UTI的多学科研究。职业发展计划的短期目标是：1）在传染病，老年医学和疗养院实践的界面上建立候选人作为以患者为导向的研究者; 2）在慢性病流行病学，传染病流行病学和纵向研究设计方面获得额外的培训和指导;以及3）获得临床试验设计，老年医学和养老院感染控制方法的技能，这将是未来研究所必需的。长期目标是培养候选人成为老年人感染领域的调查领导者，准备在长期护理机构进行多中心观察和干预性临床试验。研究计划的具体目的是：1）确定UTI特异性（例如，胁腹疼痛或压痛）和UTI非特异性（例如，精神状态的变化）临床特征; 2）鉴定疑似UTI患者中与UTI的实验室证据相关的那些可靠的临床特征（即，细菌尿加脓尿），以创建一个基于证据的定义UTI;和3），以验证临床特征的组合，这是可靠的，并与UTI的实验室证据在一个单独的验证队列的养老院居民怀疑UTI。该候选人是一位新兴的以患者为导向的调查员，在传染病和老年临床流行病学方面接受过独特的培训，这使她成为该领域调查领导者的理想人选。著名的导师，她已经聚集在耶鲁大学的环境将允许出色的培训和拟议的研究的成功完成。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Infectious diseases in the nursing home setting: challenges and opportunities for clinical investigation.

DOI：
10.1086/656411
发表时间：
2010-10-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
0
作者：
Juthani-Mehta M;Quagliarello VJ
通讯作者：
Quagliarello VJ