DATA MANAGEMENT AND STATISTICS

加州大学洛杉矶分校ADRC数据管理和统计核心（DMSC）开发了一个先进的数据管理基础设施，用于中心范围的数据处理，信息存储，数据检索和无错误的数据共享。DMSC的数据结构与国家阿尔茨海默病协调中心（NACC）完全兼容，并在上一个赠款周期的审计中达到了所有数据管理标准。错误检查程序到位，以确保持续的数据质量。具备编程技能的工作人员可对统一数据集和其他数据输出的演变作出反应 要求. DMSC数据库包括所有临床、遗传、生物标志物和NACC规定的神经病理学数据以及可用成像的清单。DMSC成员参加临床中心的评估者培训活动，以确保高质量的数据采集。除了专家数据管理外，DMSC还提供与ADRC支持的核心和项目相关的方法学，研究设计和数据分析问题的咨询。核心领导人，大卫Elashoff，博士，在分析大型蛋白质组学和基因组数据集的专业技能-智力资本，有一个重要的协同作用与ADRC的治疗必要性和生物标志物在ADRC活动的重要性日益增加的主题。DMSC的成员参加了试点项目的研究审查委员会，并就所有提交给该计划的项目提供方法和设计反馈。DMSC有一个积极的计划，指导初级教师和学员在统计方法和负责任的研究行为。DMSC教师参加执行委员会和临床研究委员会， 与招聘和教育核心合作，维护和更新ADRC网站。DMSC代表了UCLA ADRC的基本信息架构。

The UCLA ADRC Data Management and Statistics Core (DMSC) has developed a sophisticated state-of-the-art data management infrastructure for center-wide data processing, information storage, data retrieval, and errorless data sharing. The DMSC has a data structure completely compatible with the National Alzheimer Coordinating Center (NACC) and has met all standards of data management in audits of the last grant cycle. Error checking programs are in place to insure continuing data quality. Staff members with programming skills are available to respond to the evolution of the uniform data set (UDS) and other data export requirements. The DMSC database includes all clinical, genetic, biomarker, and NACC-mandated neuropathology data as well as an inventory of available imaging. DMSC members participate in rater-training activities of Clinical Core to insure quality data capture. In addition to expert data management, the DMSC provides consultation on methodologic, research design, and data analysis issues related to the Cores and Projects supported by the ADRC. The Core Leader, David Elashoff, PhD, has specialized skills in analysis of large proteomic and genomic data sets - intellectual capital that has an important synergy with the ADRC's theme of the therapeutic imperative and the increasing importance of biomarkers in ADRC activities. Members of the DMSC participate in the Research Review Committee of the Pilot Project program and provide methodologic and design feedback on all submissions to the program. The DMSC has an active program for mentoring of junior faculty and trainees in statistical methods and responsible conduct of research. DMSC faculty participate in the Executive Committee and Clinical Research Committee and collaborates with the Recruitment and Education Core in maintaining and updating the ADRC website. The DMSC represents the essential informatic architecture of the UCLA ADRC.