Cancer Cell Adaptation to Hypoxia and/or Nutrient Deprivation

癌细胞对缺氧和/或营养剥夺的适应

• 批准号: 8327680
• 负责人: CRAIG B THOMPSON
• 金额: $ 35.59万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-10 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8327680
• 关键词: 5' -AMP-activated protein kinase; ATP Synthesis Pathway; Amino Acids; Antithymoglobulin; Apoptosis; Apoptotic; Autophagocytosis; Bioenergetics; Biological Preservation; Catabolism; Cell Death; Cell Hypoxia; Cell Line; Cell Proliferation; Cell Survival; Cells; Collaborations; ERBB2 gene; Electron Transport; Enzymes; Fatty Acids; Futile Cycling; Genes; Genetic Transcription; Glucose; Glutamine; Glycolysis; Goals; Growth; Human; Hydroxylation; Hypoxia; Incidence; Investigation; Laboratories; Lead; Left; Lipids; Low Density Lipoprotein Receptor; Maintenance; Malignant - descriptor; Malignant Neoplasms; Malonyl Coenzyme A; Messenger RNA; Metabolic; Metabolic Pathway; Metabolic stress; Metabolism; Mitochondria; Molecular; Mouse Mammary Tumor Virus; Mus; Natural regeneration; Neoplasm Metastasis; Normal Cell; Nutrient; Oxidative Phosphorylation; Oxygen; Pathway interactions; Pharmaceutical Preparations; Phospholipids; Phosphotransferases; Physiological; Physiology; Polyunsaturated Fatty Acids; Production; Proliferating; Proline; Protein Biosynthesis; Proteins; Pyruvate; Reagent; Recovery; Recycling; Reducing Agents; Regulation; Relative (related person); Reporting; Risk; Role; SLC2A1 gene; Signal Transduction; Stress; Supplementation; TSC2 gene; Therapeutic; Transcriptional Activation; Transgenes; Transgenic Animals; Transgenic Organisms; Translations; Tumorigenicity; Vascular System; Work; Xenograft procedure; aerobic glycolysis; anaerobic glycolysis; base; cancer cell; cancer therapy; cell growth; cell transformation; deprivation; design; experience; extracellular; fatty acid oxidation; glucose metabolism; glucose uptake; inhibitor/antagonist; insight; lactate dehydrogenase A; lipid metabolism; neoplastic cell; novel; oxidation; promoter; protein complex; receptor expression; research study; response; small hairpin RNA; success; tumor; uptake