C-2/B: Biostatistics/Bioinformatics Core

前列腺癌孢子的生物统计学和生物信息学核心的目标是（a）维持和 继续开发SPORE的临床和组织数据库，（B）提供实验设计， 为所有SPORE项目提供流行病学和生物统计学专门知识，（c）进行数据分析，以及（d） 为孢子间和其他科学合作提供基础设施和专业知识。的专门知识 该核心的主要成员促进了SPORE临床试验、生物标志物 研究，分子诊断和高通量技术，如DNA/RNA微阵列，组织 微阵列、蛋白质组学实验和回顾性研究。生物统计学和生物信息学 核心利用生物统计学共享资源和生物信息学的现有资源和专业知识 罗伯特·H的共享资源。西北大学Lurie综合癌症中心。这 使核心能够以最低成本提供全面的生物信息学和生物统计学服务。期间 在过去的供资期间，核心小组开发了一个全面运作的、基于网络的、由CDE驱动的（共同数据 元件）用于SPORE的中央数据库，其容纳前列腺的临床、组织和实验室数据 癌症患者在西北纪念医院（NMH），杰西布朗（原湖滨）退伍军人看到 事务医疗中心（VA）和埃文斯顿西北医疗保健（ENH）的网站。创建的数据库是 对SPORE至关重要，因为它提供了获取及时和高质量特定信息的手段 关于病人的问题已制定程序收集一套标准化的数据， 从SPORE的各个组件中进行检查、编辑和输入。在下一个供资期间， 核心将扩大到包括芝加哥大学，将增加CDE的使用，包括 技术和软件来自NCI的caBIG计划。生物统计学和生物信息学核心 与临床试验和倡导核心以及标本采购核心进行了广泛的互动， 孢子。核心之间的直接交互加快了数据组织、数据管理和数据 分析，使流体创建的项目为基础的团队，为孢子项目纳入个人与 广泛的专业知识，并最大限度地提高SPORE支持的活动的效率。

The goals of the Biostatistics and Bioinformatics Core of the Prostate Cancer SPORE are (a) to maintain and continue to develop the clinical and tissue databases of the SPORE, (b) to provide experimental design, epidemiological and biostatistical expertise to all of the SPORE projects (c) to conduct data analysis and (d) to provide infrastructure and expertise for inter-SPORE and other scientific collaborations. The expertise of key members of this core facilitates planning, development and analysis of SPORE clinical trials, biomarker studies, molecular diagnostics and high throughput technologies such as DNA/RNA microarray, tissue microarray, proteomics experiments and retrospective studies. The SPORE Biostatistics and Bioinformatics Core leverages existing resources and expertise of the Biostatistics Shared Resource and the Bioinformatics Shared Resource of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. This enables the core to offer comprehensive bioinformatics and biostatistics services at minimal cost. During the past funding period, the Core has developed a fully operational, web-based, CDE-driven (common data element) central database for the SPORE that houses the clinical, tissue and laboratory data of prostate cancer patients seen at Northwestern Memorial Hospital (NMH), Jesse Brown (formerly Lakeside) Veterans Affairs Medical Center (VA), and Evanston Northwestern Healthcare (ENH) sites. The created database is essential to the SPORE as it provides means of obtaining timely and high quality specific information regarding patients in the SPORE. Procedures are in place whereby a standardized set of data are collected, checked, edited and entered from the various components of the SPORE. During the next funding period, the Core will expand to incorporate the University of Chicago, will increase the use of CDEs, incorporate technology and software coming from the NCI's caBIG initiative. The Biostatistics and Bioinformatics Core interacts extensively with the Clinical Trials and Advocacy Core and the Specimen Procurement Core of the SPORE. Direct interaction among the cores expedites data organization, data management and data analysis, enables the fluid creation of project-based teams for SPORE projects incorporating individuals with a broad range of expertise, and maximizes the efficiency of the SPORE-supported activities.