Bruker Avance III wide-bore (89-mm, 9.4T), vertical-bore 400-MHz NMR spectrometer

Bruker Avance III 大口径（89 毫米，9.4T）、垂直口径 400 MHz NMR 波谱仪

• 批准号: 8246057
• 负责人: Richard A Komoroski
• 金额: $ 59.5万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-02 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8246057
• 关键词: Alzheimer' s Disease; Animals; Biological; Biophysics; Bipolar Disorder; Brain; Cations; Cell Nucleus; Development; Encephalopathies; Funding; Head; Heart Diseases; Magic; Magnetic Resonance Spectroscopy; Malignant neoplasm of brain; Malignant neoplasm of prostate; Minor; Mus; Nanotechnology; Nuclear Magnetic Resonance; Panic Disorder; Rattus; Resolution; Sampling; Schizophrenia; Specimen; Stroke; Tissue Sample; Tissues; Tube; human disease; instrument; malignant breast neoplasm

DESCRIPTION (provided by applicant): We are requesting funds to purchase a nuclear magnetic resonance (NMR) spectrometer (Bruker Biospin Avance III 400WB at 9.4T) to perform advanced analyses in support of studies of a wide range of human diseases. The spectrometer will have a wide range of capabilities including: 1) MR microimaging (MRI) and magnetic resonance spectroscopy (MRS) of small animals, including rat and mouse head, mouse body, tissue samples, and other small biological specimens, for a variety of NMR nuclei; 2) magic angle spinning NMR to obtain high resolution NMR spectra of intact tissue samples for 1H, 31P, and 13C; 3) standard multinuclear NMR for nuclei such as 1H, 31P, 6,7Li, 13C, 15N, 19F, 17O, and 23Na, using both 5-mm and 10-mm sample tubes. Seven major users (or user groups) with projects in prostate cancer, stroke, bipolar disorder, heart disease, brain development, encephalopathy, and cation biophysics will occupy about 75% of the instrument initially, using all of the capabilities listed above. Minor and other users, with projects in Alzheimers disease; breast, prostate, and brain cancers; schizophrenia; bipolar and panic disorders; and nanotechnology, as well as users yet to be identified, will occupy the remaining 25% of the instrument, using all of the capabilities listed above.

描述（由申请人提供）：我们正在申请资金购买核磁共振（NMR）光谱仪（Bruker Biospin Avance III 400 WB，9.4T），以进行高级分析，支持对各种人类疾病的研究。该谱仪将具有广泛的功能，包括：1）小动物的MR显微成像（MRI）和磁共振波谱（MRS），包括大鼠和小鼠头部、小鼠身体、组织样本和其他小生物样本，用于各种NMR核; 2）魔角旋转NMR，以获得完整组织样本的1H、31 P和13 C的高分辨率NMR谱; 3）使用5-mm和10-mm样品管的标准多核NMR，用于诸如1H、31 P、6，7 Li、13 C、15 N、19 F、17 O和23 Na的核。在前列腺癌、中风、双相情感障碍、心脏病、脑发育、脑病和阳离子生物物理学方面有项目的七个主要用户（或用户组）最初将占据仪器的75%左右，使用上面列出的所有功能。未成年人和其他用户，项目涉及阿尔茨海默病;乳腺癌、前列腺癌和脑癌;精神分裂症;躁郁症和恐慌症;以及纳米技术，以及尚未确定的用户，将占据仪器的剩余25%，使用上面列出的所有功能。