Mouse Transplantation

小鼠移植

• 批准号: 8212938
• 负责人: SAUL Joseph SHARKIS
• 金额: $ 24.1万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8212938
• 关键词: Biological; Breeding; Cellular biology; Engraftment; Eye; Goals; Hematopoietic Stem Cell Transplantation; Injury; Malignant Neoplasms; Monitor; Mouse Strains; Mus; Resources; Services; Tissues; Transgenic Mice; Transgenic Organisms; Transplantation; Variant; animal care; cancer stem cell; cell type; design; programs

Mouse Transplantation (Core Component B) This core is designed to provide centralized, specialized animal care for several strains of mice to include breeding of Nod/Scid and variants as well as EGFP and Flt3 transgenics. Breeding of immuno-deficient and transgenic mice are necessary because many of these strains are not commercially available either in quantities needed for our studies or not at all. The large number of mice to be transplanted and monitored for engraftment represents the other major function of the core. We believe providing the expertise centrally for these services is efficient both scientifically and financially. Relevance The identification of tissue specific and cancer stem cells are the primary goals of this program project. The core will provide a resource to help identify these rare cell types and establish the biology of these cells with an eye toward using the biological information gained toward treating cancer and injury.

小鼠移植（核心组件B） 该核心旨在为几个品系的小鼠提供集中的、专门的动物护理， Nod/Scid和变体以及EGFP和Flt 3转基因的育种。免疫缺陷和 转基因小鼠是必要的，因为这些品系中的许多在商业上是不可获得的， 我们的研究所需的数量，或者根本不需要。大量的老鼠被移植和监测， 移植是核心的另一项主要职能。我们相信集中提供专业知识， 这些服务在科学上和财政上都是有效的。 相关性 组织特异性和癌症干细胞的鉴定是该计划项目的主要目标。的 核心将提供一个资源，以帮助确定这些罕见的细胞类型，并建立这些细胞的生物学， 着眼于将获得的生物信息用于治疗癌症和损伤。