TRANSCERVICAL POLIDOCANOL FOAM AS NONSURGICAL FEMALE STERILIZATION TECHNIQUE

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 高生育率是地球上许多最贫穷地区的地方病。 由于各种原因，可逆方法是不切实际的。因此，迫切需要安全和低成本的非手术方法进行女性和男性绝育。 本计画将利用猕猴模型来探索一种新的非手术女性绝育方法。 本项目的目的是探索经宫颈输送聚多卡醇泡沫将选择性损伤输卵管上皮并导致输卵管阻塞而不损伤非靶组织（如子宫腔或腹腔内器官）的假设。 具体目标是：（1）开发一种可重现的技术，用于对猕猴宫颈插管并评估体内输卵管通畅性;（2）确定经宫颈给予聚多卡醇泡沫是否会导致体内观察到的输卵管阻塞;以及3）描述聚多卡醇泡沫对生殖道和非靶组织的大体和显微组织效应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. High rates of human fertility are endemic in many of the poorest areas on earth. Reversible methods are impractical for a variety of reasons. Therefore, safe and low cost non-surgical methods of female and male sterilization are urgently needed. This project will use the macaque model to explore a novel approach for non-surgical female sterilization. The purpose of this project is to explore the hypotheses that Polidocanol foam delivered transcervically will selectively damage the fallopian tube epithelium and result in tubal blockage without injury to non-target tissues such as the uterine cavity or intra abdominal organs. The Specific Aims are to: (1) develop a reproducible technique to cannulate the macaque cervix and assess tubal patency in vivo; (2) determine if Polidocanol foam administered transcervically will result in tubal blockade observed in vivo; and 3) describe the gross and microscopic tissue effects of Polidocanol foam on the reproductive tract and non-target tissues.