TAS::75 0893::TAS RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE

TAS::75 0893::TAS 尼古丁代谢物快速定量护理点测试

• 批准号: 8354109
• 负责人: ANIRUDDHA PUNTAMBEKAR
• 金额: $ 99.73万
• 依托单位: SILOAM BIOSCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8354109
• 关键词: Bedside Testings; Cancer Etiology; Cessation of life; Clinical Research; Cotinine; Enzymes; Goals; Healthcare; Measurement; Nicotine; Pharmaceutical Preparations; Physicians; Small Business Innovation Research Grant; Smoking; Techniques; Testing; addiction; cytochrome P-450 CYP2A6 (human); enzyme activity; hydroxycotinine; liquid chromatography mass spectrometry; mortality; nicotine replacement; programs; smoking cessation

Recent clinical research has established that this ratio is indicative of the activity of the CYP2A6 enzyme that metabolises nicotine. Nicotine is metabolized to COT and then to 3HC. People with high activity of this enzyme, clear nicotine faster and hence need more nicotine to maintain the addiction. To-date the 3HC/COT ratio could only be determined by specialized measurement techniques such as Liquid-Chromatography/Mass Spectrometry. Although accurate, these tests are expensive and take 2-5 days to deliver results. Smoking is the leading cause of cancer related deaths, and is attributable cause for almost 400,000 deaths per year in the US> The POCT for nicotine metabolites can help in increasing smoking cessation rates and directly contribute to reduced mortality/healthcare burden.

最近的临床研究证实，该比率表明了代谢尼古丁的 CYP2A6 酶的活性。尼古丁代谢为COT，然后代谢为3HC。这种酶活性高的人可以更快地清除尼古丁，因此需要更多的尼古丁来维持成瘾。迄今为止，3HC/COT 比率只能通过专门的测量技术（例如液相色谱/质谱法）来确定。尽管准确，但这些测试价格昂贵，并且需要 2-5 天才能得出结果。 吸烟是癌症相关死亡的主要原因，在美国每年有近 400,000 人死亡> 尼古丁代谢物的 POCT 有助于提高戒烟率，并直接有助于降低死亡率/医疗负担。