TAS::75 0893::TAS RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE

最近的临床研究已经确定，该比率指示代谢尼古丁的CYP 2A 6酶的活性。尼古丁代谢为COT，然后代谢为3 HC。这种酶活性高的人，清除尼古丁的速度更快，因此需要更多的尼古丁来维持成瘾。迄今为止，3 HC/COT比率只能通过专门的测量技术，如液相色谱/质谱法来确定。虽然准确，但这些测试是昂贵的，需要2-5天才能提供结果。 吸烟是癌症相关死亡的主要原因，并且是美国每年近400，000例死亡的归因原因>尼古丁代谢物的POCT可以帮助提高戒烟率，并直接有助于降低死亡率/医疗保健负担。

Recent clinical research has established that this ratio is indicative of the activity of the CYP2A6 enzyme that metabolises nicotine. Nicotine is metabolized to COT and then to 3HC. People with high activity of this enzyme, clear nicotine faster and hence need more nicotine to maintain the addiction. To-date the 3HC/COT ratio could only be determined by specialized measurement techniques such as Liquid-Chromatography/Mass Spectrometry. Although accurate, these tests are expensive and take 2-5 days to deliver results. Smoking is the leading cause of cancer related deaths, and is attributable cause for almost 400,000 deaths per year in the US> The POCT for nicotine metabolites can help in increasing smoking cessation rates and directly contribute to reduced mortality/healthcare burden.