Roles of protective or pathogenic B cell epitopes in human Lassa Fever

保护性或致病性 B 细胞表位在人类拉沙热中的作用

• 批准号: 8256732
• 负责人: JAMES ROBINSON
• 金额: $ 1272.42万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256732
• 关键词: Aerosols; Africa; Algorithms; Antibodies; Antibody Formation; Antibody-mediated protection; Area; B-Lymphocyte Epitopes; Biological; Biological Assay; Bioterrorism; Case Fatality Rates; Categories; Clinical; Containment; Contracts; Development; Diagnosis; Diagnostic; Emerging Communicable Diseases; Enzyme-Linked Immunosorbent Assay; Epitopes; Goals; Guinea; Health Benefit; Human; Humoral Immunities; Immune response; Immunotherapeutic agent; Laboratories; Lassa Fever; Lassa fever virus; Lassa virus; Measures; Mediating; Military Personnel; National Institute of Allergy and Infectious Disease; Nigeria; Pathogenesis; Public Health; Reagent; Recombinant Proteins; Research; Resources; Role; Sierra Leone; Toxin; Vaccines; Viral Hemorrhagic Fevers; Viral Proteins; base; biodefense; design; improved; in vivo; mathematical model; novel; pathogen; prevent; programs; prototype; therapeutic vaccine; weapons

The goal of the B Cell Epitope Discovery and Mechanisms of Antibody Production program is to identify novel B cell epitopes and elucidate novel mechanisms of antibody-mediated protection or pathogenesis that are important in humoral immunity in humans to emerging and re-emerging infectious diseases and potential agents of bioterrorism and their toxins. Results from this B cell epitope discovery program will advance our understanding of antibody functions and greatly facilitate the design and development of improved immunotherapeutics, diagnostics, and vaccines. In addition, an expansion of the list of known B cell epitopes and antibody functions will facilitate the development of more robust algorithms and mathematical models to predict B cell epitopes and antibody-mediated immune responses to pathogens and toxins in vivo. This contract will identify epitopes from Lassa Fever virus.

B细胞表位发现和抗体产生机制项目的目标是鉴定新的B细胞表位，阐明抗体介导的保护或发病机制的新机制，这些机制在人类对新发和再发感染性疾病和生物恐怖主义及其毒素的潜在因子的体液免疫中非常重要。该B细胞表位发现计划的结果将促进我们对抗体功能的理解，并极大地促进改进的免疫治疗剂、诊断剂和疫苗的设计和开发。此外，已知的B细胞表位和抗体功能的列表的扩展将促进更稳健的算法和数学模型的开发，以预测体内B细胞表位和抗体介导的对病原体和毒素的免疫应答。该合同将鉴定拉沙热病毒的表位。