Meharry RCMI Program in Women's Health Research

Meharry RCMI 妇女健康研究项目

• 批准号: 8299573
• 负责人: Wayne Joseph Riley
• 金额: $ 229.78万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8299573
• 关键词: AIDS/HIV problem; African American; Applications Grants; Award; Behavioral Sciences; Bioinformatics; Caucasians; Caucasoid Race; Color; Core Facility; Development; Dimensions; Disease; Ehrlichiosis; Faculty; Female; Flow Cytometry; Fostering; Genes; Genetic Polymorphism; Genomics; Goals; HIV-1; Health Personnel; Health Status; Hispanics; Human; Human Resources; Immune; Incidence; Mental Health; Mentors; Mission; Peer Review; Physicians; Pilot Projects; Pregnancy; Premature Birth; Proteomics; Publications; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Resources; Scientist; Senior Scientist; Time; Tissues; Uterine Fibroids; Vitamin D Deficiency; Vitamin Deficiency; Woman; Women' s Health; biomedical scientist; diabetic gastroparesis; experience; health disparity; improved; medical schools; next generation; programs; success

The long range goal of this RCMI program renewal application is to expand and improve the capacity for women's health research, including HIV/AIDS at Meharry Medical College (MMC), placing particular emphasis on those diseases that disproportionately impact women of color. Numerous reports have documented differences in health status between Caucasian women and women of color, particularly African American (AA) and Hispanic Women. In the current application we seek to increase the capacity for women's health research at MMC by providing ongoing support for two recently hired RCMI investigators. Dr. P. Gangula will continue his studies on diabetic gastroparesis, which has a 4-times greater incidence in women, and Dr. N. Ismail will study immune regulation of human monocytic ehrlichiosis during pregnancy. We plan to recruit three mental health/behavioral science investigators to add this dimension of women's health research. In the pilot project core: Dr. X. Dong will study HIV-1 assembly, Dr. S. Halder will study Vitamin D deficiency and uterine fibroids in AA women and Dr. C. Thota will seek to correlate gene polymorphism and hypovitaminosis D in preterm birth. A strong team of senior scientists will facilitate a robust mentoring and faculty development experience for all RCMI Investigators. Two existing core facilities (Proteomic and Genomic & BL3/Flow Cytometry) will be merged /upgraded and a new core facility (Female Tissue Acquisition Core) will be developed. The RCMI program will be interfaced with other MMC research programs and the RTRN network to expand and enhance the resources and opportunities for investigators. The specific aims of the current application are to 1) exceed a 3 year average of 2 peer-reviewed publications/year/RCMI Investigator by the end of the award period; 2) to facilitate submission of investigator-initiated grant applications by all RCMI Investigators prior to their 3rd year of support; 3) to exceed 50% of RCMI investigators acquiring investigator-initiated support by the end of the award cycle; and 4) to have documented evidence that RCMI supported core facilities, bioinformatics support, as well as RTRN support were appropriately leveraged to achieve the above successes.

该 RCMI 计划更新申请的长期目标是扩大和提高梅哈里医学院 (MMC) 的妇女健康研究能力，包括艾滋病毒/艾滋病研究能力，特别强调那些对有色人种妇女影响尤为严重的疾病。许多报告记录了白人女性和有色人种女性，特别是非裔美国人 (AA) 和西班牙裔女性之间健康状况的差异。在当前的申请中，我们寻求通过为最近聘用的两名 RCMI 研究人员提供持续支持来提高 MMC 的妇女健康研究能力。 P. Gangula 博士将继续研究糖尿病性胃轻瘫，该病在女性中的发病率是女性的 4 倍，而 N. Ismail 博士将研究妊娠期间人类单核埃利希体病的免疫调节。我们计划招募三名心理健康/行为科学研究人员来增加女性健康研究的这一维度。在试点项目核心中：X. Dong 博士将研究 HIV-1 组装，S. Halder 博士将研究 AA 女性的维生素 D 缺乏和子宫肌瘤，C. Thota 博士将寻求将基因多态性与早产中维生素 D 缺乏症联系起来。强大的资深科学家团队将为所有 RCMI 研究者提供强有力的指导和教师发展经验。两个现有的核心设施（蛋白质组学和基因组学和 BL3/流式细胞术）将被合并/升级，并将开发一个新的核心设施（女性组织采集核心）。 RCMI 计划将与其他 MMC 研究计划和 RTRN 网络相结合，以扩大和增强研究人员的资源和机会。当前申请的具体目标是 1) 在奖励期结束时超过 2 篇同行评审出版物/年/RCMI 研究者的 3 年平均水平； 2) 促进所有 RCMI 研究者在第三年支持之前提交研究者发起的资助申请； 3) 在奖励周期结束时，超过 50% 的 RCMI 研究者获得研究者发起的支持； 4) 有记录证据表明 RCMI 支持核心设施、生物信息学支持以及 RTRN 支持被适当利用以实现上述成功。