Ethical, Legal, and Social Implications in Military Genomics

描述(申请人提供)：基因组科学的进步吸引了美国军方的兴趣，因为它们有潜力改善军队成员的医疗保健，并帮助军队招募、培训和专业化，以及完成任务。此外，军方运营的大型DNA银行可能是军方和民间研究人员的宝贵资源。虽然ELSI研究项目探索了在广泛的背景下使用基因组科学所引起的问题，但除了与国防部DNA注册处的法医使用有关的问题外，几乎没有对军事基因组学所引起的伦理、法律和社会问题进行审查。该项目将把来自ELSI计划的见解和关于基因组科学所构成的伦理、法律和社会问题的更广泛的对话带到军方潜在使用基因组科学所带来的独特挑战上来。在目前正在为军事生物强化制定生物伦理框架的基础上，该项目将构建第一个军事基因组学的生物伦理和法律框架，并将利用这一框架分析如何解决ELSI问题。 公共卫生相关性：该项目将为军事基因组学构建一个伦理和法律框架，并将该框架应用于美国军方设想的基因组科学的使用。这将通过阐明道德和 通过建立和利用拟议的新的军事/退伍军人DNA生物库的法律适当方式，并就如何随着军队增加使用基因组学而保护军人及其家属的健康和福祉提出建议。

DESCRIPTION (provided by applicant): Advances in genomic science are attracting the interest of the U.S. military for their potential to improve medical care for members of the militay and to aid in military recruitment, training and specialization, and mission accomplishment. In addition, large DNA banks operated by the military could be a valuable resource for military and civilian researchers. While ELSI research projects have explored issues raised by the use of genomic science in a wide variety of contexts, there has been virtually no examination of the ethical, legal, and social issues raised by military genomics beyond those relating to forensic use of the Department of Defense (DoD) DNA Registry. This project will bring the insights from the ELSI program and the broader conversation on the ethical, legal, and social issues posed by genomic science in general to bear on the unique challenges presented by potential uses of genomic science by the military. Building on work now underway to develop a bioethical framework for military bioenhancement, this project will construct the first bioethical and legal framework for military genomics, and will employ this framework to analyze how ELSI issues might be resolved. PUBLIC HEALTH RELEVANCE: This project will construct an ethical and legal framework for military genomics and apply this framework would apply to uses of genomic science contemplated by the U.S. military. This will promote the public health by elucidating ethically and legally appropriate ways to construct and utilize a proposed new military/VA DNA biobank, and by offering suggestions for how to protect the health and well-being of members of the military and their families as the military increases its uses of genomics.