AIDS INFRASTRUCTURE AND RESEARCH DEVELOPMENT

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目标一.扩大我们目前的研究团队，招募博士后候选人，并通过全面的发展计划提高他们的职业生涯 目标1.确定并招聘三名合适的候选人。 目标2.从研究小组的当前需求出发，与候选人和绩效指标协商，为每个候选人制定一个研究项目和计划。 目标二：建立必要的组织结构，以加强Nef病因学小组(NPG)的研究和资金投入。 目的1.设立艾滋病毒/艾滋病发病咨询小组委员会。 目标2.为小组活动建立研究支持。 目标3.在男男性接触者中组织艾滋病毒研究的各个组成部分 目的4.增强我们现有的蛋白质组学和成像能力，以支持病因学组的研究。 研究重点：了解HIV-1Nef导致艾滋病的致病作用和机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective I. Extend our current research team recruiting postdoctoral candidates, and enhancing their careers through a comprehensive developmental program AIM 1. Identify and recruit three suitable candidates. AIM 2. Develop a research project and plan for each candidate from the current needs of the research group with consultation between the candidate and the PIs. Objective II. Establish the organizational structure necessary to enhance the research and the funding of the Nef Pathogenesis Group (NPG). AIM 1. Establish an HIV/AIDS Pathogenesis Advisory Subcommittee. AIM 2. Build research support for the group activities. AIM 3. Organize the various components of HIV research at MSM AIM 4. Enhance our current proteomics and imaging capability to support research of the Pathogenesis group. Research Focus: Understanding the Role Played by and Mechanisms Underlying HIV-1 Nef's Pathogenic Effects Leading to AIDS.