R&D-OTHER R & D-B RES

安捷伦建议开发高深度分辨率、高速度和高灵敏度的兔眼全前房体积光学相干显微成像技术，以定量评估眼刺激试验中初始损伤(001)的深度和程度。由Jester博士开创的研究提供了强有力的证据，表明001是一种客观和通用的生物标志物，可以在远早于当前定义的人体终点的时间点确定各种化学品的毒性严重程度。Agiltron提出的4-0(X、Y、Z、t)光学相干成像具有超高深度分辨率、大深度范围、大区域覆盖等特点。此外，超高速还能有效去除活体动物的运动伪影。因此，影像技术为准确评估早期损伤的深度、面积、体积以及恢复过程中的后期反应提供了最合适的工具。

Agiltron proposes to develop volumetric optical coherence microscopic imaging technology for the full anterior chamber of the rabbit eye with high depth resolution, high speed, and high sensitivity to quantitatively assess the depth and extent of initial injury (001) in ocular irritant test. Studies pioneered by Dr. Jester have provided strong evidence that 001 is an objective and universal biomarker to determine the severity of toxicity for various chemicals at time points much earlier than currently defined humane endpoints. The 4-0 (X, Y, Z, and t) optical coherence imaging proposed by Agiltron has the key properties in ultrahigh depth resolution, large depth range, and wide area coverage. In addition, the ultrahigh speed can effectively remove motion artifacts of living animals. Therefore the imaging technology provides the most appropriate tool to accurately evaluate the depth, area, and volume of the initial injury as well as the later responses in recovery. In particular, novel 3D registration and segmentation technology will be developed to enable the point-to-point comparison of the irritation progression and wound healing at the same tissue vicinity (XYZ dimensions) but different time points (t dimension) for quantitative, objective, and sensitive ocular safety assessments as well as the earlier human endpoints.