TELOMERE LENGTH IN NUCLEATE BLOOD CELLS FROM BABOONS OF VARIOUS AGES

不同年龄狒狒有核血细胞的端粒长度

• 批准号: 8357653
• 负责人: PETER M LANSDORP
• 金额: $ 0.02万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357653
• 关键词: Age; Animals; Biological Aging; Blood Cells; Chromosome Mapping; Chromosomes; Funding; Genetic; Grant; Human; Length; Link; National Center for Research Resources; Papio; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Surrogate Markers; United States National Institutes of Health; Variant; cost; genetic pedigree; telomere

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of the study is to analyze the telomere (ends of a chromosome) length in various blood cells from normal healthy baboons in relation to their age. We have found in normal humans that the telomere length in various blood cells clearly declines with age. This finding suggests that the telomere length can be used as a surrogate marker for biological age. We would like to know if the same applies to other large outbred animals such as baboons. An additional rationale for the study is that by inclusion of animals with a detailed pedigree and genetic map we hope to link variation in telomere length with specific genetic loci.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项研究的目的是分析不同血细胞中端粒(染色体末端)的长度与其年龄的关系。我们在正常人身上发现，各种血细胞中的端粒长度明显随着年龄的增长而下降。这一发现表明，端粒长度可以作为生物年龄的替代标记。我们想知道这是否同样适用于其他大型远交动物，如狒狒。这项研究的另一个理由是，通过纳入具有详细系谱和遗传图谱的动物，我们希望将端粒长度的变化与特定的遗传位点联系起来。