TELOMERE LENGTH IN NUCLEATE BLOOD CELLS FROM BABOONS OF VARIOUS AGES

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这项研究的目的是分析正常健康狒狒的各种血细胞中端粒（染色体末端）长度与年龄的关系。我们发现，在正常人中，各种血细胞中的端粒长度随着年龄的增长而明显下降。这一发现表明端粒长度可以作为生物年龄的替代标记。我们想知道这是否同样适用于其他大型远系繁殖动物，如狒狒。这项研究的另一个基本原理是，通过纳入具有详细系谱和遗传图谱的动物，我们希望将端粒长度的变化与特定的遗传位点联系起来。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of the study is to analyze the telomere (ends of a chromosome) length in various blood cells from normal healthy baboons in relation to their age. We have found in normal humans that the telomere length in various blood cells clearly declines with age. This finding suggests that the telomere length can be used as a surrogate marker for biological age. We would like to know if the same applies to other large outbred animals such as baboons. An additional rationale for the study is that by inclusion of animals with a detailed pedigree and genetic map we hope to link variation in telomere length with specific genetic loci.