LSUHSC COBRE: IMMUNE CORRELATES OF BKV PERSISTENCE AND REACTIVATION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 子项目2：BKV持续和重新激活的免疫相关性 约翰·A·万奇埃尔 BK病毒(BKV)已经成为肾移植和干细胞移植受者发病的重要原因，这种出现突显了我们对这种无处不在的病毒自然历史的认识的重大缺陷。BKV的无症状重新激活和脱落在免疫低下时期是常见的，包括怀孕，但正常维持BKV潜伏期的宿主免疫因素知之甚少。孕期BKV的重新激活为探索与BKV脱落相关的免疫激活以及影响BKV在儿童早期传播的宿主因素提供了独特的机会，而不存在与器官移植和严重的免疫损害相关的混杂因素。这一建议的中心假设是，母体免疫因素有助于BKV在怀孕期间重新激活，最终影响BKV从母亲到孩子的传播。这些研究将确定人类感染BKV的自然历史，包括识别婴儿早期促进BKV传播的事件、母体BKV重新激活时激活的免疫途径以及婴儿对BKV感染的免疫反应。深入了解BKV感染的自然历史，对于今后研究BKV相关疾病的发病机制和治疗具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Subproject #2: Immune Correlates of BKV Persistence and Reactivation John A. Vanchiere BK virus (BKV) has emerged as an important cause of morbidity in kidney and stem cell transplant recipients, and this emergence has underscored the significant deficits in our knowledge of the natural history of this ubiquitous virus. Asymptomatic reactivation and shedding of BKV is common during periods of immune compromise, including pregnancy, but the host immune factors that normally maintain BKV latency are poorly understood. BKV reactivation during pregnancy presents a unique opportunity to explore the immune activation associated with BKV shedding and the host factors that influence transmission of BKV during early childhood without the confounding factors associated with organ transplantation and severe immune compromise. The central hypothesis of this proposal is that maternal immune factors contribute to the reactivation of BKV during pregnancy, ultimately influencing the transmission of BKV from mother to child. These studies will define the natural history of BKV infection in humans, including the identification of events in early infancy that facilitate BKV transmission, the immune pathways activated in response to maternal BKV reactivation and the infant immune response to BKV infection. An improved understanding of the natural history of BKV infection is crucial to the development of future studies of the pathogenesis and treatment of BKV-related disease.