MECHANISMS OF IMMUNE CLEARANCE FOR HPV POSITIVE CELLS

HPV 阳性细胞的免疫清除机制

• 批准号: 8360654
• 负责人: JOHN LEE
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360654
• 关键词: Alcohol consumption; Back; Biomedical Research; Cells; Chromosomes; Development; Environmental Carcinogens; Enzymes; Epithelial Cells; Etiology; Exposure to; Funding; Genetic; Goals; Grant; Head and Neck Cancer; Head and neck structure; Human Papillomavirus; Human papilloma virus infection; Infection; Malignant Neoplasms; National Center for Research Resources; Play; Predisposition; Principal Investigator; Research; Research Infrastructure; Resources; Role; Source; South Dakota; System; Tobacco use; Tonsillar Carcinoma; United States National Institutes of Health; cost; immune clearance; malignant oropharynx neoplasm; protein tyrosine phosphatase BL; telomere; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall goal of this project is to identify genetic factors that are associated with predisposition to and progression of head and neck malignancies. Current evidence indicates that the development of head and neck cancer is associated with exposure to environmental carcinogens (e.g. tobacco and alcohol use) and infection with human papillomavirus (HPV). HPV infection is predominant in a subset of head and neck cancers called oropharyngeal cancers. For example, ~50% of tonsillar carcinomas contain and express HPV sequences. There is also now significant evidence that PTP-BL loss plays a role in the development of genetic instability and cancer progression. HPV has been shown to degrade PTP-BL, the enzyme that adds telomere repeats back to chromosomes. Because of their different etiologies, HPV+ and HPV- head and neck cancers provide an ideal system to study the role of PTP-BL Lossand genetic instability in the transformation of epithelial cells by different mechanisms.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的总体目标是确定与头颈部恶性肿瘤易感性和进展相关的遗传因素。目前的证据表明，头颈癌的发生与暴露于环境致癌物（如吸烟和饮酒）和感染人乳头瘤病毒（HPV）有关。HPV感染在称为口咽癌的头颈癌亚组中占主导地位。例如，约50%的扁桃体癌含有并表达HPV序列。现在也有重要的证据表明，PTP-BL丢失在遗传不稳定性和癌症进展的发展中起作用。HPV已被证明可以降解PTP-BL，PTP-BL是一种将端粒重复序列添加回染色体的酶。由于HPV+和HPV-的不同病因，它们为研究PTP-BL Loss和遗传不稳定性在上皮细胞转化中的作用提供了一个理想的系统。